ArticleGenetics in medicine : official journal of the American College of Medical Genetics2021
Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- An integrated cardiometabolic genetic testing program in a predominantly Hispanic population within a community setting.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Accelerating rare disease diagnostics by linking DNA and RNA through an explainable and interactive RNA-guided workflow.NAR genomics and bioinformatics · 2026Article
- The impact of genetic testing on physician practice in specialized cardiovascular clinics.Journal of clinical lipidology · 2026Article
- Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.Nature reviews. Cardiology · 2026Review
- Development of a comprehensive cardiovascular disease genetic risk assessment test.Genetics in medicine open · 2026Article
- Functional Profiling ofCirculation. Genomic and precision medicine · 2025Article
- Emerging risk factors for heart failure in younger populations: A growing public health concern.World journal of cardiology · 2025Review
- Troponin I - a comprehensive review of its function, structure, evolution, and role in muscle diseases.Animal cells and systems · 2025Review
- Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk.BMC medical genomics · 2024Article
- Experiences across a genetic screening and testing programme pathway: a qualitative study of mammogram patient perspectives.BMJ open · 2024Article
- Protocol for a type 3 hybrid implementation cluster randomized clinical trial to evaluate the effect of patient and clinician nudges to advance the use of genomic medicine across a diverse health system.Implementation science : IS · 2024Article
- Development of a comprehensive cardiovascular disease genetic risk assessment test.medRxiv : the preprint server for health sciences · 2024Article
- Closing the gap: Solving complex medically relevant genes at scale.medRxiv : the preprint server for health sciences · 2024Article
- The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities.Communications biology · 2024Article
- Tracking updates in clinical databases increases efficiency for variant reanalysis.Genetics in medicine open · 2024Article
- Integrative Genetic Approach Facilitates Precision Strategies for Acute Myocardial Infarction.Genes · 2023Review
- Genetic Testing for Familial Hypercholesterolemia in Clinical Practice.Current atherosclerosis reports · 2023Review
- Real-world utilization of guideline-directed genetic testing in inherited cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Article
- Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study.Circulation. Genomic and precision medicine · 2022Article
- Genome Sequencing in the Parkinson Disease Clinic.Neurology. Genetics · 2022Article
Corrections and comments
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Authors and funding
39 authors at 3 institutions in 1 country.
Funding
Abstract
purposeCardiovascular disease (CVD) is the leading cause of death in adults in the United States, yet the benefits of genetic testing are not universally accepted.
methodsWe developed the "HeartCare" panel of genes associated with CVD, evaluating high-penetrance Mendelian conditions, coronary artery disease (CAD) polygenic risk, LPA gene polymorphisms, and specific pharmacogenetic (PGx) variants. We enrolled 709 individuals from cardiology clinics at Baylor College of Medicine, and samples were analyzed in a CAP/CLIA-certified laboratory. Results were returned to the ordering physician and uploaded to the electronic medical record.
resultsNotably, 32% of patients had a genetic finding with clinical management implications, even after excluding PGx results, including 9% who were molecularly diagnosed with a Mendelian condition. Among surveyed physicians, 84% reported medical management changes based on these results, including specialist referrals, cardiac tests, and medication changes. LPA polymorphisms and high polygenic risk of CAD were found in 20% and 9% of patients, respectively, leading to diet, lifestyle, and other changes. Warfarin and simvastatin pharmacogenetic variants were present in roughly half of the cohort.
conclusionOur results support the use of genetic information in routine cardiovascular health management and provide a roadmap for accompanying research.
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