ArticleNPJ breast cancer2021
Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation.
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Article in NPJ breast cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
42 citing papers in PubMed, 52 citations in OpenAlex.
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- MuTriM: A multiscale deep learning model integrating longitudinal radiomics and pathomic features for predicting recurrence and adjuvant radiation benefit in breast cancer.European journal of cancer (Oxford, England : 1990) · 2026Article
- Whole-slide mapping of tumor tissue fiber architecture via computational scattered light imaging.Biomedical optics express · 2026Article
- Normal breast tissue (NBT)-classifiers: advancing compartment classification in normal breast histology.NPJ breast cancer · 2026Article
- Multimodal deep learning for cancer prognosis prediction with clinical information prompts integration.NPJ digital medicine · 2025Article
- Collagen disorder architecture features are associated with clinical, molecular, genetic factors and survival outcomes in colon cancer.NPJ precision oncology · 2025Article
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- Deep learning assessment of metastatic relapse risk from digitized breast cancer histological slides.Nature communications · 2025Article
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- Quantitative and qualitative metrics of tumor stroma in predicting ovarian cancer outcomes and expansion of its study with AI-based tools.Molecular therapy. Oncology · 2025Review
- Distinct roles of protrusions and collagen deformation in collective invasion of cancer cell types.Biophysical journal · 2025Article
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- Mechanisms of breast cancer metastasis: the role of extracellular matrix.Molecular and cellular biochemistry · 2025Review
- Exploring racial differences in second-harmonic-generation-based prognostic indicators of metastasis in breast and colon cancer.Biophotonics discovery · 2025Article
- Artificial intelligence in digital pathology - time for a reality check.Nature reviews. Clinical oncology · 2025Review
- Quantifying and interpreting biologically meaningful spatial signatures within tumor microenvironments.NPJ precision oncology · 2025Review
- Histolytics: A panoptic spatial analysis framework for interpretable histopathology.Computational and structural biotechnology journal · 2025Article
- Publicly available datasets of breast histopathology H&E whole-slide images: A scoping review.Journal of pathology informatics · 2024Article
- Ten challenges and opportunities in computational immuno-oncology.Journal for immunotherapy of cancer · 2024Review
- White Light Diffraction Phase Microscopy in Imaging of Breast and Colon Tissues.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Haojia LiCase Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA. hxl735@case.edu.ORCID http://orcid.org/0000-0001-5000-5334
Kaustav BeraCase Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-9831-6000
Paula ToroCase Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA.
PingFu FuCase Western Reserve University, Department of Population and Quantitative Health Sciences, School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-2334-5218
Zelin ZhangNanjing University of Information Science and Technology, Jiangsu Key Laboratory of Big Data Analysis Technique, Nanjing, China.
Cheng LuCase Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA.
Michael FeldmanUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Shridar GanesanRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Lori J GoldsteinFox Chase Cancer Center, Philadelphia, PA, USA.
Nancy E DavidsonFred Hutchinson Cancer Research Center, University of Washington, and Seattle Cancer Care Alliance, Seattle, WA, USA.
Akisha GlasgowUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Aparna HarbhajankaUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Hannah GilmoreUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Anant MadabhushiCase Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA. axm788@case.edu.ORCID http://orcid.org/0000-0002-5741-0399
Case Western Reserve University · USUniversity Hospitals of Cleveland · USFox Chase Cancer Center · USLouis Stokes Cleveland VA Medical Center · USNanjing University of Information Science and Technology · CNRutgers, The State University of New Jersey · USSeattle Cancer Care Alliance · USUniversity of Pennsylvania · US
Funding
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MPathology CoreU54CA254566 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MADABHUSHI, ANANT · 2020 to 2024
$5.0MHutchinson Center as Lead Academic Participating Site (UG1)UG1CA233328 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Evan Yu · 2019 to 2026
$4.3MComputerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1MQuantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1MComputerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1MMR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0MPathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9MRadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4MHistoTools: A suite of digital pathology tools for quality control, annotation and dataset identificationU01CA239055 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JANOWCZYK, ANDREW ROBERT, MADABHUSHI, ANANT · 2019 to 2022
$1.0MA Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear SlidesR43EB028736 · NIBIB · DIASCOPIC, LLC · PI MADABHUSHI, ANANT, SERIF, CARY · 2019 to 2019
$225kBIOMEDICAL ENGINEERING RESEARCH FACILITIESC06RR012463 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI KUTINA, KENNETH L · 1997 to 1997
–BLRD VA I01 BX004121NCATS NIH HHS UL1 TR002548NCI NIH HHS R01 CA202752NCI NIH HHS R01 CA208236NCI NIH HHS R01 CA216579NCI NIH HHS R01 CA220581NCI NIH HHS U01 CA239055NCI NIH HHS U01 CA248226NCI NIH HHS U24 CA199374NCI NIH HHS U54 CA254566NCI NIH HHS UG1 CA233328NCRR NIH HHS C06 RR012463NIBIB NIH HHS R43 EB028736
Abstract
Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named M
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