Evidence map›Paper›PMID 34362904›Full record

ArticleNature communications2021

Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy.

Na Kong, Hanjie Zhang, Chan Feng, Chuang Liu, Yufen Xiao, Xingcai Zhang, Lin Mei, Jong Seung Kim, Wei Tao, Xiaoyuan Ji

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 213 citations in OpenAlex.

  1. Review
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  6. Multiscale Construction, Evaluation, and Application of Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Periodic Table of Immunomodulatory Elements and Derived Two-Dimensional Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Review
  14. Review
  15. Valence-Change MnOJournal of the American Chemical Society · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Na KongCenter for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hanjie ZhangAcademy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, China.
Chan FengCenter for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Chuang LiuCenter for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yufen XiaoCenter for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xingcai ZhangSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7114-1095
Lin MeiTianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.ORCID 0000-0001-6503-5149
Jong Seung KimDepartment of Chemistry, Korea University, Seoul, Korea.ORCID 0000-0003-3477-1172
Wei TaoCenter for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. wtao@bwh.harvard.edu.ORCID 0000-0002-4277-3728
Xiaoyuan JiCenter for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jixiaoyuan@tju.edu.cn.ORCID 0000-0002-6768-2304
Brigham and Women's Hospital · USChinese Academy of Medical Sciences & Peking Union Medical College · CNHarvard University · USKorea University · KRTianjin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/As

Indexed as

NanomedicineA549 CellsAnimalsApoptosisArsenicCatalysisCell Line, TumorGlutathioneHomeostasisHumansHydrogen PeroxideIndolesMCF-7 CellsMiceMice, Inbred C57BLNanoparticlesArsenicGlutathioneHydrogen PeroxideIndolesOxygenPhotosensitizing AgentspolydopaminePolymersReactive Oxygen Species

Identifiers

PMID34362904
PMCPMC8346549
OpenAlexW3192239848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.