ArticleNature communications2021
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Canonical and Non-Canonical Regulators of Lipid Metabolism in the Liver and the "Liver-Other Organs" Axes.International journal of molecular sciences · 2026Review
- Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice.Molecular metabolism · 2026Article
- Article
- Gut Microbiota-Bile Acid Axis in Type 2 Diabetes-Associated Gallbladder Diseases: Mechanisms and Therapeutic Potential.Metabolites · 2026Review
- Integrating bile acid metabolism into precision nutrition strategies for improved swine performance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- Microbial changes resulting from VSG attenuate MASLD by modulating bile acid metabolism and the intestinal FXR-FGF19 axis.mSystems · 2025Article
- Intestinal Dysbiosis Caused by EpithelialImmune network · 2025Article
- The role of the gut-brain axis in bariatric surgery.Current opinion in neurobiology · 2025Review
- Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue.Molecular metabolism · 2025Article
- Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia.Nature metabolism · 2025Article
- Impact of Sleeve Gastrectomy on Body Weight and Food Intake Regulation in Diet-Induced Obese Mice.Current issues in molecular biology · 2024Article
- Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development.Pharmacological reviews · 2024Review
- Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss.Diabetes & metabolism · 2024Article
- A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery.Cell host & microbe · 2024Article
- Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.JCI insight · 2024Article
- Targeting the FGF19-FGFR4 pathway for cholestatic, metabolic, and cancerous diseases.Journal of internal medicine · 2024Review
- The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism.Nutrients · 2023Review
- Prolonged Antibiotic Exposure during Adolescence Dysregulates Liver Metabolism and Promotes Adiposity in Mice.The American journal of pathology · 2023Article
- Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Nadejda Bozadjieva-KramerDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Jae Hoon ShinDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Yikai ShaoCenter for Obesity and Metabolic Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Ruth Gutierrez-AguilarDivsión de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México and Laboratorio de Enfermedades Metabólicas: Obesidad y Diabetes, Hospital Infantil de México "Federico Gómez", Mexico, Mexico.ORCID 0000-0001-5077-9102
Ziru LiDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Kristy M HeppnerNovo Nordisk Research Center Seattle, Inc, Seattle, WA, USA.
Samuel ChiangDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Sara G VargoDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Katrina GrangerDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Darleen A SandovalDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ormond A MacDougaldDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA. seeleyrj@med.umich.edu.ORCID 0000-0002-3721-5625
University of Michigan · USFudan University · CNHospital Infantil de México Federico Gómez · MXNovo Nordisk (United States) · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9MPUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3MInterdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0MNational Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MMichigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2MPostdoc Stipend Supplement: Developmental Origins of Metabolic Disorders T32T32DK071212 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON, Kanakadurga Singer · 2005 to 2026
$5.4MRoles for Wnt Signaling in Adipose TissueR01DK062876 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2003 to 2018
$5.1MNCATS NIH HHS UL1 TR002240NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR044927NIAMS NIH HHS R01 AR065424NIAMS NIH HHS R29 AR044927NIDDK NIH HHS N02 DK062876NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P60 DK020572NIDDK NIH HHS R01 DK107282NIDDK NIH HHS R01 DK121759NIDDK NIH HHS R01 DK121995NIDDK NIH HHS R24 DK084970NIDDK NIH HHS R24 DK092759NIDDK NIH HHS T32 DK071212NIDDK NIH HHS T32 DK108740NIDDK NIH HHS U24 DK097153NIDDK NIH HHS U2C DK110768NIDDK NIH HHS U2C DK119886
Abstract
Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19 which is increased after VSG and pharmacologically can improve energy homeostasis and glucose handling. We generated intestinal-specific FGF15 knockout (FGF15
Indexed as
Adipose TissueAnimalsBariatric SurgeryBile Acids and SaltsBlood GlucoseBone DensityBone MarrowDiabetes Mellitus, Type 2Diet, High-FatDisease Models, AnimalFibroblast Growth FactorsGastrectomyGlucose Tolerance TestHomeostasisMaleMiceBile Acids and SaltsBlood Glucosefibroblast growth factor 15, mouseFibroblast Growth Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.