ArticleBMJ open2021
Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Health diagnosis associated with COVID-19 death in the United States: A retrospective cohort study using electronic health records.PloS one · 2025Article
- Article
- A High Respiratory Drive Is Associated with Weaning Failure in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome: The Role of the Electrical Activity of the Diaphragm.Journal of clinical medicine · 2024Article
- Characteristics of and Outcomes in COVID-19 Critical Care Patients in the Qassim Region, Saudi Arabia.Cureus · 2023Article
- Use of high flow nasal cannula oxygen therapy for patients infected with SARS-CoV-2 outside intensive care setting.Journal of thoracic disease · 2023Article
- Formation of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) in the electrochemical oxidation of polluted waters with pharmaceuticals used against COVID-19.Journal of environmental chemical engineering · 2023Article
- Measuring SARS-CoV-2 aerosolization in rooms of hospitalized patients.Laryngoscope investigative otolaryngology · 2022Article
- Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells.Drug development research · 2022Article
- Trends in characteristics and outcomes among US adults hospitalised with COVID-19 throughout 2020: an observational cohort study.BMJ open · 2022Observational
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Authors and funding
26 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine age, gender, and temporal differences in baseline characteristics and clinical outcomes of adult patients hospitalised with COVID-19.
designA cohort study using deidentified electronic medical records from a Global Research Network. SETTING/
participants67 456 adult patients hospitalised with COVID-19 from the USA; 7306 from Europe, Latin America and Asia-Pacific between February 2020 and January 2021.
resultsIn the US cohort, compared with patients 18-34 years old, patients ≥65 had a greater risk of intensive care unit (ICU) admission (adjusted HR (aHR) 1.73, 95% CI 1.58 to 1.90), acute respiratory distress syndrome(ARDS)/respiratory failure (aHR 1.86, 95% CI 1.76 to 1.96), invasive mechanical ventilation (IMV, aHR 1.93, 95% CI, 1.73 to 2.15), and all-cause mortality (aHR 5.6, 95% CI 4.36 to 7.18). Men appeared to be at a greater risk for ICU admission (aHR 1.34, 95% CI 1.29 to 1.39), ARDS/respiratory failure (aHR 1.24, 95% CI1.21 to 1.27), IMV (aHR 1.38, 95% CI 1.32 to 1.45), and all-cause mortality (aHR 1.16, 95% CI 1.08 to 1.24) compared with women. Moreover, we observed a greater risk of adverse outcomes during the early pandemic (ie, February-April 2020) compared with later periods. In the ex-US cohort, the age and gender trends were similar; for the temporal trend, the highest proportion of patients with all-cause mortality were also in February-April 2020; however, the highest percentages of patients with IMV and ARDS/respiratory failure were in August-October 2020 followed by February-April 2020.
conclusionsThis study provided valuable information on the temporal trends of characteristics and outcomes of hospitalised adult COVID-19 patients in both USA and ex-USA. It also described the population at a potentially greater risk for worse clinical outcomes by identifying the age and gender differences. Together, the information could inform the prevention and treatment strategies of COVID-19. Furthermore, it can be used to raise public awareness of COVID-19's impact on vulnerable populations.
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