ArticleThe British journal of ophthalmology2023
Population-based associations between progression of normal-tension glaucoma and Yang-deficient constitution among Chinese persons.
Article in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Relationship between long-term blood pressure fluctuations and visual field progression in primary open-angle glaucoma: a prospective cohort study.Eye and vision (London, England) · 2026Article
- Tear proteomics reveals biomarkers for visual field progression in normal-tension glaucoma.International journal of ophthalmology · 2026Article
- Identification of characteristic genes ofanddeficiency constitutions: an integrated analysis based on bioinformatics and machine learning.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma.Investigative ophthalmology & visual science · 2024Observational
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12 authors.
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Abstract
purposeTo explore the association between constitution types as defined by traditional Chinese medicine (TCM) and risk for normal-tension glaucoma (NTG).
designPopulation-based cohort study.
methodsPersons were identified in a population cohort aged ≥30 years with NTG, defined as having an untreated mean intraocular pressure measurement ≤21 mm Hg over six separate occasions, with no single reading >24 mm Hg (as in the Collaborative Normal Tension Glaucoma Study). The Body Constitution in Traditional Chinese Medicine Questionnaire was used to assess each participant's TCM constitution types. The association between various constitutions and visual field progression according to Early Manifest Glaucoma Trial criteria was assessed using Cox regression HR models.
resultsAmong 142 participants (245 eyes), 23 persons (17.6%) and 25 eyes (10.2%) progressed, over a mean (SD) follow-up duration of 3.49 (0.99) years. Progression rates were highest in participants with Yang-deficient constitution (n=19, 13.4%), among whom 7 (36.8%) exhibited worsening fields. After adjusting for sex, age, central corneal thickness, retinal nerve fibre layer thickness and mean deviation on visual field testing, Yang-deficient constitution (HR 4.63, 95% CI 1.77 to 12.1, p=0.002) and higher mean intraocular pressure during follow-up (HR 1.25, 95% CI 1.01 to 1.56, p=0.044) were associated with field progression.
conclusionsYang-deficient constitution and higher intraocular pressure are risk factors for visual field progression in NTG patients. Yang deficiency is characterised by abnormal vasoregulation, and these results may be consistent with prior studies linking NTG progression to Raynaud's phenomenon and migraine.
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