Evidence map›Paper›PMID 34362732›Full record

ArticleScience advances2021

The structural basis of bacterial manganese import.

Stephanie L Neville, Jennie Sjöhamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm and 6 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cryo-electron microscopy structure of a zinc uptake ABC transporter.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Hfe Permease andACS infectious diseases · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023
    Review
  18. Zinc acquisition and its contribution toFrontiers in cellular and infection microbiology · 2023
    Article
  19. Structure and Function of the Zinc Binding Protein ZrgA fromInternational journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stephanie L NevilleDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7298-9335
Jennie SjöhamnDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9360-6279
Jacinta A WattsDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Hugo MacDermott-OpeskinResearch School of Chemistry, Australian National University, Canberra, ACT, Australia.ORCID http://orcid.org/0000-0002-7393-7457
Stephen J FairweatherResearch School of Chemistry, Australian National University, Canberra, ACT, Australia.ORCID http://orcid.org/0000-0003-1530-7876
Katherine GanioDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-7360-6466
Alex Carey HulyerDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Aaron P McGrathDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Andrew J HayesDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-8038-1656
Tess R MalcolmSchool of Chemistry and The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Mark R DaviesDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-6141-5179
Norimichi NomuraDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
So IwataDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-1735-2937
Megan L O'MaraResearch School of Chemistry, Australian National University, Canberra, ACT, Australia.ORCID http://orcid.org/0000-0002-8764-1585
Megan J MaherDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia. megan.maher@unimelb.edu.au christopher.mcdevitt@unimelb.edu.au.ORCID http://orcid.org/0000-0003-0848-9640
Christopher A McDevittDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. megan.maher@unimelb.edu.au christopher.mcdevitt@unimelb.edu.au.ORCID http://orcid.org/0000-0003-1596-4841

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import pathway for many micronutrients including the first-row transition metal manganese. However, the structural features of ionic metal transporting ABC permeases have remained undefined. Here, we present the crystal structure of the manganese transporter PsaBC from

Identifiers

PMID34362732
PMCPMC8346216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.