Evidence map›Paper›PMID 34362655›Full record

ReviewSeminars in cell & developmental biology2022

Growth and mechanobiology of the tendon-bone enthesis.

Megan L Killian

Open access · hybridAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. [Research progress on the role and mechanism of magnesium element and magnesium materials in tendon-bone interface healing].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  6. Article
  7. Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  8. Mechanical Strain-Programmed SDC1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Megan L KillianUniversity of Michigan, Michigan Medicine, Department of Orthopaedic Surgery, 109 Zina Pitcher Place, Ann Arbor 48109, MI, USA. Electronic address: mlkillia@med.umich.edu.
Michigan Medicine · US

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
GENETIC DETERMINATION OF SKELETAL FRAGILITYR01AR044927 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JEPSEN, KARL J · 2002 to 2014
$4.3M
Bone Robustness as a Biomarker of Skeletal Aging and FragilityR01AR065424 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JEPSEN, KARL J · 2014 to 2018
$2.4M
FGF signaling during growth and mechanical adaptation of tendon-bone interfacesR01AR079367 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KILLIAN, MEGAN L. · 2021 to 2025
$2.0M
GENETIC DETERMINATION OF SKELETAL FRAGILITYR29AR044927 · NIAMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI JEPSEN, KARL J · 1998 to 2002
$268k
Contributions of skeletal muscle loading during rotator cuff maturation and healingR03HD094594 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KILLIAN, MEGAN LEIGH · 2018 to 2019
$156k
NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR044927NIAMS NIH HHS R01 AR065424NIAMS NIH HHS R01 AR079367NIAMS NIH HHS R29 AR044927NICHD NIH HHS R03 HD094594
6 · The paper itself

Abstract

Tendons are cable-like connective tissues that transfer both active and passive forces generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is an interfacial zone of transitional tissue located between two mechanically dissimilar tissues: compliant, fibrous tendon to rigid, dense mineralized bone. In this review, we focus on emerging areas in enthesis development related to its structure, function, and mechanobiology, as well as highlight established and emerging signaling pathways and physiological processes that influence the formation and adaptation of this important transitional tissue.

Indexed as

Bone and BonesTendonsBiophysicsMuscle, SkeletalSignal TransductionEnthesisFibrocartilageMuscle loadingTendon

Identifiers

PMID34362655
PMCPMC8810906
OpenAlexW3190760441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.