Observational studyCritical care (London, England)2021
Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study.
Observational study in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04346342 (PRactice of VENTilation in COVID-19 Patients), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRactice of VENTilation in COVID-19 Patients (PRoVENT-COVID) - an Observational Study of Invasively Ventilated Patients in the Netherlands
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between Mechanical Power and Mortality in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis.Critical care medicine · 2026Pooled it
- Mechanical Power as a Predictor of Outcomes During Mechanical Ventilation in Coronavirus Disease 2019 (COVID-19): An Updated Systematic Review.Journal of clinical medicine · 2026Review
- Is Mechanical Power the Trojan Horse? Emphasizing the Role of Driving Pressure.Medicina (Kaunas, Lithuania) · 2025Article
- Mechanical power is an early predictor of mortality in mechanically ventilated patients with COVID-19.BMJ open respiratory research · 2025Article
- Effect of decreasing respiratory rate on the mechanical power of ventilation and lung injury biomarkers: a randomized cross-over clinical study in COVID-19 ARDS patients.Intensive care medicine experimental · 2025Article
- Adaptive Pressure Control-Continuous Mandatory Ventilation Versus Volume Control-Continuous Mandatory Ventilation: Factors Associated With Initiation, Maintenance, and Adjustment.Respiratory care · 2024Article
- Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data.European journal of medical research · 2024Observational
- [Linear power and mortality in COVID-19 respiratory difficulty syndrome].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Effect of Ventilator Settings on Mechanical Power During Simulated Mechanical Ventilation of Patients With ARDS.Respiratory care · 2024Article
- Development and evaluation of a mechanical ventilator-sharing system.Frontiers in medicine · 2024Article
- Mechanical Power of Ventilation: From Computer to Clinical Implications.Respiratory care · 2023Review
- The Bayes factor in the analysis of mechanical power in patients with severe respiratory failure due to SARS-CoV-2.Medicina intensiva · 2023Article
- Mechanical power and 30-day mortality in mechanically ventilated, critically ill patients with and without Coronavirus Disease-2019: a hospital registry study.Journal of intensive care · 2023Article
- Dexmedetomidine and Propofol Sedation in Critically Ill Patients: How Much Is Too Much?American journal of respiratory and critical care medicine · 2023Article
- [The Bayes factor in the analysis of mechanical power in patients with severe respiratory failure due to SARS-CoV-2].Medicina intensiva · 2023Article
- The COVIDTW study: Clinical predictors of COVID-19 mortality and a novel AI prognostic model using chest X-ray.Journal of the Formosan Medical Association = Taiwan yi zhi · 2023Article
- Mechanical Power in Prone Position Intubated Patients with COVID-19-Related ARDS: A Cohort Study.Critical care research and practice · 2023Article
- Accuracy of calculating mechanical power of ventilation by one commonly used equation.Journal of clinical monitoring and computing · 2022Article
- Mechanical power is associated with weaning outcome in critically ill mechanically ventilated patients.Scientific reports · 2022Article
- Associations of dynamic driving pressure and mechanical power with postoperative pulmonary complications-posthoc analysis of two randomised clinical trials in open abdominal surgery.EClinicalMedicine · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients with or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar association exists in coronavirus disease 2019 (COVID-19) patients with acute respiratory failure.
methodsWe aimed to investigate the impact of intensity of ventilation on patient outcome. The PRoVENT-COVID study is a national multicenter observational study in COVID-19 patients receiving invasive ventilation. Ventilator parameters were collected a fixed time points on the first calendar day of invasive ventilation. Mean dynamic ΔP and MP were calculated for individual patients at time points without evidence of spontaneous breathing. A Cox proportional hazard model, and a double stratification analysis adjusted for confounders were used to estimate the independent associations of ΔP and MP with outcome. The primary endpoint was 28-day mortality.
resultsIn 825 patients included in this analysis, 28-day mortality was 27.5%. ΔP was not independently associated with mortality (HR 1.02 [95% confidence interval 0.88-1.18]; P = 0.750). MP, however, was independently associated with 28-day mortality (HR 1.17 [95% CI 1.01-1.36]; P = 0.031), and increasing quartiles of MP, stratified on comparable levels of ΔP, had higher risks of 28-day mortality (HR 1.15 [95% CI 1.01-1.30]; P = 0.028).
conclusionsIn this cohort of critically ill invasively ventilated COVID-19 patients with acute respiratory failure, we show an independent association of MP, but not ΔP with 28-day mortality. MP could serve as one prognostic biomarker in addition to ΔP in these patients. Efforts aiming at limiting both ΔP and MP could translate in a better outcome. Trial registration Clinicaltrials.gov (study identifier NCT04346342).
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