Evidence map›Paper›PMID 34362409›Full record

ArticleTrials2021

The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) program: study protocol for a randomized controlled trial.

Kar-Fu Yeung, Mihir Gandhi, Amanda Yun Rui Lam, Selly Julianty, Alvin Yeow Meng Chia, Gilbert Choon Seng Tan, Su-Yen Goh, Emily Tse Lin Ho, Angela Fang Yung Koh, Gavin Siew Wei Tan and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03503942. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03503942 nacompleted

The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program

Ran2017Enrolled751Registered outcomes8Posted comparisons0ConditionsPre-diabetesArmsFinancial incentives, Lifestyle Modification, Metformin
Open the trial in the graph
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Kar-Fu YeungCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
Mihir GandhiCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
Amanda Yun Rui LamDepartment of Endocrinology, Singapore General Hospital, Singapore, Singapore.
Selly JuliantySingHealth Duke-NUS Diabetes Centre, Singapore, Singapore.
Alvin Yeow Meng ChiaSingHealth Duke-NUS Diabetes Centre, Singapore, Singapore.
Gilbert Choon Seng TanSingHealth Duke-NUS Diabetes Centre, Singapore, Singapore.
Su-Yen GohDepartment of Endocrinology, Singapore General Hospital, Singapore, Singapore.
Emily Tse Lin HoDepartment of Endocrinology, Singapore General Hospital, Singapore, Singapore.
Angela Fang Yung KohSingHealth Duke-NUS Diabetes Centre, Singapore, Singapore.
Gavin Siew Wei TanSingHealth Duke-NUS Diabetes Centre, Singapore, Singapore.
Eugene Jin Wen ShumRegional Health System Office, SingHealth, Singapore, Singapore.
Eric A FinkelsteinHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Tazeen H JafarHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Yee Leong TeohBiostatistics, Singapore Clinical Research Institute, Singapore, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Clare WhittonSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Julian ThumbooDepartment of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.
Yong Mong BeeDepartment of Endocrinology, Singapore General Hospital, Singapore, Singapore. bee.yong.mong@singhealth.com.sg.ORCID http://orcid.org/0000-0002-5482-2646
SingHealth · SGDuke-NUS Medical School · SGSingapore General Hospital · SGNational University of Singapore · SGSingapore National Eye Center · SGSingHealth Duke-NUS Academic Medical Centre · SGSingapore Clinical Research Institute · SGTampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommunity-based diabetes prevention programs varied widely in effectiveness, and the intervention strategy consisting of lifestyle interventions, stepwise addition of metformin, and financial incentives has not been studied in real-world clinical practice settings. The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) trial is a pragmatic trial that aims to compare the effectiveness of a community-based stepwise diabetes prevention program with added financial incentives (intervention) versus the standard of care (control) in reducing the risk of type 2 diabetes over 3 years among overweight or obese individuals with pre-diabetes.

methodsThis is an open-label, 1:1 randomized controlled trial which aims to recruit 846 adult individuals with isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), or both IFG and IGT from Singapore. Intervention arm participants attend 12 group-based sessions (2 nutrition workshops, 9 exercise sessions, and a goal-setting workshop) delivered at community sites (weeks 1 to 6), receive weekly physical activity and nutrition recommendations delivered by printed worksheets (weeks 7 to 12), and receive monthly health tips delivered by text messages (months 4 to 36). From month 6 onwards, intervention arm participants who remain at the highest risk of conversion to diabetes are prescribed metformin. Intervention arm participants are also eligible for a payment/rewards program with incentives tied to attendance at the group sessions and achievement of the weight loss target (5% of baseline weight). All participants are assessed at baseline, month 3, month 6, and every 6 months subsequently till month 36. The primary endpoint is the proportion of participants with diabetes at 3 years. Secondary endpoints include the mean change from baseline at 3 years in fasting plasma glucose, 2-hour plasma glucose, HbA1c, body weight, body mass index, physical activity, and dietary intake. DISCUSSION: The Pre-DICTED trial will provide evidence of the effectiveness and feasibility of a community-based stepwise diabetes prevention program with added financial incentives for individuals with pre-diabetes in Singapore. The study will provide data for a future cost-effectiveness analysis, which will be used to inform policymakers of the value of a nationwide implementation of the diabetes prevention program.

trial registrationClinicalTrials.gov NCT03503942 . Retrospectively registered on April 20, 2018. Protocol version: 5.0 Date: 1 March 2019.

Indexed as

Diabetes Mellitus, Type 2Prediabetic StateAdultHumansLife StyleObesityOverweightPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicDiabetesPre-diabetesPrevention

Identifiers

PMID34362409
PMCPMC8349028
OpenAlexW3169397372

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.