Evidence map›Paper›PMID 34362405›Full record

ArticleJournal of nanobiotechnology2021

Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring.

Junhao Su, Xinhao Duan, Yu Qiu, Lixiao Zhou, Hongyang Zhang, Min Gao, Yijun Liu, Zhen Zou, Jingfu Qiu, Chengzhi Chen

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Toxicologic Concerns with Current Medical Nanoparticles.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Interactions between Nanoparticles and Intestine.International journal of molecular sciences · 2022
    Review
  14. Exposure to two-dimensional ultrathin TiJournal of nanobiotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Junhao Su *Department of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Xinhao Duan *Department of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Yu Qiu *Department of Neurology, The Affiliated University-Town Hospital of Chongqing Medical University, Chongqing, 401331, People's Republic of China.
Lixiao ZhouDepartment of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Hongyang ZhangDepartment of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Min GaoDepartment of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Yijun LiuDepartment of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Zhen ZouMolecular Biology Laboratory of Respiratory Diseases, Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, People's Republic of China. zouzhen@cqmu.edu.cn.ORCID https://orcid.org/0000-0002-1651-591X
Jingfu QiuDepartment of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China. jfqiu@126.com.ORCID https://orcid.org/0000-0003-1220-7319
Chengzhi ChenDongsheng Lung-Brain Disease Joint Lab, Chongqing Medical University, Chongqing, 400016, People's Republic of China. chengzhichen@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-1087-4911
Chongqing Public Health Medical Center · CNChongqing Medical University · CN

Funding

National Natural Science Foundation of China 81602820
6 · The paper itself

Abstract

backgroundPregnancy exposure to titanium dioxide nanoparticles (TiO

methodsIn the present study, the pregnant mice were intragastric administered with 150 mg/kg TiO

resultsThe results clearly demonstrated that exposure to TiO

conclusionsThis is the first report elucidated that pregnancy exposure to TiO

Indexed as

AnimalsBrain-Gut AxisDysbiosisFemaleGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLNanoparticlesPregnancyTitaniumTitaniumtitanium dioxideIntestinal dysbiosisNeurobehavioral impairmentsPregnancy exposureTitanium dioxide nanoparticles

Identifiers

PMID34362405
PMCPMC8349049
OpenAlexW3190782483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.