Evidence map›Paper›PMID 34362362›Full record

ArticleBMC oral health2021

The role of 25-hydroxyvitamin-D3 and vitamin D receptor gene in human periodontal ligament fibroblasts as response to orthodontic compressive strain: an in vitro study.

Erika Calvano Küchler, Agnes Schröder, Vinicius Broska Teodoro, Ute Nazet, Rafaela Scariot, Gerrit Spanier, Peter Proff, Christian Kirschneck

Open access · goldAbstract readAddress
In one paragraph

Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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  12. Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms inJournal of oral biology and craniofacial research
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Erika Calvano KüchlerDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Agnes SchröderDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Vinicius Broska TeodoroPrivate Practice Curitiba, Paraná, Brazil.
Ute NazetDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Rafaela ScariotDepartment of Stomatology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Gerrit SpanierDepartment of Maxillofacial Surgery, University of Regensburg, Regensburg, Germany.
Peter ProffDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Christian KirschneckDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. christian.kirschneck@klinik.uni-regensburg.de.
University of Regensburg · DEUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate, if different physiological concentrations of vitamin D (25(OH)D

methodsA pool of hPDL fibroblasts was treated in absence or presence of 25(OH)D

resultsRANKL, RANKL:OPG ratio, COX-2, IL-6, DHCR7, CYP2R1 and AMDHD1 were differentially expressed during simulated orthodontic compressive strain (p < 0.05). The RANKL:OPG ratio was downregulated by all concentrations (10 ng/ml, 40 ng/ml and 60 ng/ml) of 25(OH)D

conclusionsSimulated orthodontic compressive strain and physiological concentrations of 25(OH)D

Indexed as

Periodontal LigamentReceptors, CalcitriolCalcifediolFibroblastsHumansVitamin DCalcifediolReceptors, CalcitriolVitamin DGenePolymorphismTooth movementVitamin D

Identifiers

PMID34362362
PMCPMC8344219
OpenAlexW3187962415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.