Evidence map›Paper›PMID 34362288›Full record

ArticlePharmaceutical biology2021

Tultul Saha, Joydeep Aoun, Paramita Sarkar, Andrea J Bourdelais, Daniel G Baden, Normand Leblanc, John M Hamlyn, Owen M Woodward, Kazi Mirajul Hoque

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Pharmaceuticals (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tultul SahaPathophysiology Division, National Institute of Cholera & Enteric Diseases, Kolkata, India.
Joydeep AounPathophysiology Division, National Institute of Cholera & Enteric Diseases, Kolkata, India.
Paramita SarkarPathophysiology Division, National Institute of Cholera & Enteric Diseases, Kolkata, India.
Andrea J BourdelaisCenter for Marine Science, University of North Carolina, Wilmington, NC, USA.
Daniel G BadenCenter for Marine Science, University of North Carolina, Wilmington, NC, USA.
Normand LeblancDepartment of Pharmacology, The Center for Cardiovascular Research, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV, USA.
John M HamlynDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Owen M WoodwardDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-9514-2180
Kazi Mirajul HoquePathophysiology Division, National Institute of Cholera & Enteric Diseases, Kolkata, India.ORCID https://orcid.org/0000-0001-5604-8650
University of Maryland, Baltimore · USNational Institute of Cholera and Enteric Diseases · INUniversity of Nevada, Reno · USUniversity of North Carolina Wilmington · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
Role of ANO1 Channels and Its Regulation by PIP2 in EC-Coupling in Pulmonary Artery MyocytesR01HL146054 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT, LEBLANC, NORMAND · 2019 to 2022
$2.0M
NHLBI NIH HHS R01 HL146054NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

contextCucumber (

objectiveThis study investigated the effect of MATERIALS AND

methodsCCE extracts were obtained from commercially available cucumber. Active fractions were then purified by HPLC and analysed by high resolution mass spectrometry. The effect of CCE on intestinal chloride secretion was investigated in human colonic T84 cells,

resultsCCE increased the short-circuit current (ΔIsc 34.47 ± µA/cm

conclusionA cucurbitacin-like analog present in CCE activates TMEM16A channels, which may have therapeutic potential in cystic fibrosis and intestinal hypodynamic disorders.

Indexed as

AnimalsAnoctamin-1Cell LineChloridesConstipationCucumis sativusGastrointestinal MotilityHumansIntestinesIon ChannelsLoperamideMaleMiceMice, Inbred C57BLModels, AnimalMuscle, SmoothAnoctamin-1ChloridesIon ChannelsLoperamidePlant ExtractsLoperamide-induced C57BL/6 constipation mouse modelT84 cells

Identifiers

PMID34362288
PMCPMC8354179
OpenAlexW3192861332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.