Evidence map›Paper›PMID 34362190›Full record

ArticleJournal of clinical medicine2021

Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction.

Akisato Nishigaki, Yuhuko Ichikawa, Minoru Ezaki, Akitaka Yamamoto, Kenji Suzuki, Kei Tachibana, Toshitaka Kamon, Shotaro Horie, Jun Masuda, Katsutoshi Makino and 5 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Biomarkers of Hypercoagulability in COVID-19.Journal of clinical medicine · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  14. The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  15. D-dimer kit with a High FDP/D-Dimer Ratio is Useful for Diagnosing Thrombotic Diseases.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  16. Usefulness of Clot Waveform Analysis-Activated Thromboplastin Time (APTT) for Diagnosing Thrombotic Diseases.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Akisato NishigakiDepartment of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Yuhuko IchikawaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Minoru EzakiDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Akitaka YamamotoDepartment of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Kenji SuzukiDepartment of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Kei TachibanaDepartment of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Toshitaka KamonDepartment of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Shotaro HorieDepartment of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Jun MasudaDepartment of Cardiovascular Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Katsutoshi MakinoDepartment of Cardiovascular Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Katsuya ShirakiDepartment of Laboratory and General Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Hideto ShimpoMie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Motomu ShimaokaDepartment of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.ORCID 0000-0003-1930-3397
Katsue Suzuki-InoueDepartment of Clinical and Laboratory Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Hideo WadaDepartment of Laboratory and General Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.ORCID 0000-0001-9021-8633

Funding

Japanese Ministry of Health, Labor and Welfare 21FC1008
6 · The paper itself

Abstract

backgroundAcute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. MATERIALS AND

methodsThe plasma sCLEC-2 and D-dimer levels were measured using the STACIA system.

resultsThe plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis.

conclusionUsing both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.

Indexed as

acute cerebral infarction (ACI)atherosclerotic ACIcardioembolic ACIplatelet activationsCLEC-2

Identifiers

PMID34362190
PMCPMC8348423

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.