Evidence map›Paper›PMID 34362093›Full record

ArticleJournal of clinical medicine2021

Usefulness of a Hepatitis B Surface Antigen-Based Model for the Prediction of Functional Cure in Patients with Chronic Hepatitis B Virus Infection Treated with Nucleos(t)ide Analogues: A Real-World Study.

Gian Paolo Caviglia, Yulia Troshina, Enrico Garro, Marcantonio Gesualdo, Serena Aneli, Giovanni Birolo, Fabrizia Pittaluga, Rossana Cavallo, Giorgio Maria Saracco, Alessia Ciancio

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gian Paolo CavigliaDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.ORCID 0000-0002-0529-9481
Yulia TroshinaDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.
Enrico GarroDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.
Marcantonio GesualdoDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.
Serena AneliDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.ORCID 0000-0003-4303-2507
Giovanni BiroloDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.ORCID 0000-0003-0160-9312
Fabrizia PittalugaMicrobiology Unit, A.O.U. Città della Salute e della Scienza, 10126 Torino, Italy.
Rossana CavalloMicrobiology Unit, A.O.U. Città della Salute e della Scienza, 10126 Torino, Italy.
Giorgio Maria SaraccoDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.ORCID 0000-0001-5310-4143
Alessia CiancioDepartment of Medical Sciences, University of Torino, 10123 Turin, Italy.
University of Turin · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with chronic hepatitis B (CHB) under long-term treatment with nucleso(t)ide analogues (NAs), the loss of hepatitis B surface antigen (HBsAg) is a rare event. A growing body of evidence supports the use of quantitative HBsAg for the prediction of functional cure, although these results are mainly derived from studies performed on Asian patients with hepatitis B e antigen (HBeAg)-positive CHB. Here, we investigated the clinical role of quantitative HBsAg in a real-life cohort of CHB patients under treatment with NAs in a tertiary care center from North-West Italy. A total of 101 CHB patients (HBeAg-negative,

Indexed as

antiviral therapybiomarkerchronic liver diseaseHBsAgHBV

Identifiers

PMID34362093
PMCPMC8348455
OpenAlexW3184713412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.