ArticleJournal of clinical medicine2021
Risk of Heart Disease after Cholecystectomy: A Nationwide Population-Based Cohort Study in South Korea.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Pooled it
- Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses.BMC medicine · 2023Pooled it
- Mendelian randomization reveals the causal relationship between cholecystectomy and ischemic stroke.BMC neurology · 2026Article
- Depression and long-term mortality among 5-year breast cancer survivors in Korea: a retrospective population-based cohort study.Scientific reports · 2026Article
- Fifteen-year impact of cholecystectomy on multiple organs.Clinical and molecular hepatology · 2026Article
- Protocol for the development of a procedure guide on Laparoscopic Cholecystectomy: Beyond bile duct injury prevention.PloS one · 2026Article
- Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study.Scientific reports · 2024Article
- Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats.Nutrients · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of the study is to evaluate the risk of heart disease in individuals who underwent cholecystectomy. This was a retrospective cohort study using the National Health Insurance Service database of South Korea. A total of 146,928 patients who underwent cholecystectomy and 268,502 age- and sex-matched controls were compared. Multivariate Cox proportional hazard regression analysis was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for heart disease after cholecystectomy. In results, a previous history of cholecystectomy increased the risk of heart disease (congestive heart failure [CHF], myocardial infarction [MI], atrial fibrillation [AF]) (adjusted HR [aHR]: 1.40, 95% CI: [1.36-1.44]). The increased risk was particularly seen for CHF (1.22 [1.16-1.29]) but not for MI and AF (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.