Evidence map›Paper›PMID 34362007›Full record

ArticleJournal of clinical medicine2021

Identifying and Avoiding Risk of Bias in Caries Diagnostic Studies.

Jan Kühnisch, Mila Janjic Rankovic, Svetlana Kapor, Ina Schüler, Felix Krause, Stavroula Michou, Kim Ekstrand, Florin Eggmann, Klaus W Neuhaus, Adrian Lussi and 1 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jan KühnischDepartment of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, 80336 Munich, Germany.ORCID 0000-0003-4063-2291
Mila Janjic RankovicDepartment of Orthodontics and Dentofacial Orthopaedics, University Hospital, Ludwig-Maximilians University Munich, 80336 Munich, Germany.
Svetlana KaporDepartment of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, 80336 Munich, Germany.
Ina SchülerDepartment of Orthodontics, Section of Preventive and Paediatric Dentistry, University Hospital, 07743 Jena, Germany.
Felix KrauseClinic for Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Stavroula MichouDepartment of Odontology, University Copenhagen, 2200 Copenhagen, Denmark.
Kim EkstrandDepartment of Odontology, University Copenhagen, 2200 Copenhagen, Denmark.
Florin EggmannDepartment of Periodontology, Endodontology and Cariology, University Center for Dental Medicine UZB, University of Basel, 4058 Basel, Switzerland.ORCID 0000-0001-6185-1480
Klaus W NeuhausDepartment of Periodontology, Endodontology and Cariology, University Center for Dental Medicine UZB, University of Basel, 4058 Basel, Switzerland.ORCID 0000-0002-4686-1362
Adrian LussiSchool of Dental Medicine, University of Bern, 3012 Bern, Switzerland.
Marie-Charlotte HuysmansDepartment of Dentistry, Radboud University Medical Centre, 6525 Nijmegen, The Netherlands.

Funding

Deutsche Forschungsgemeinschaft SCHU-3217/1-1
6 · The paper itself

Abstract

Caries diagnostic studies differ with respect to their design, included patients/tooth samples, use of diagnostic and reference methods, calibration, blinding and data reporting. Such heterogeneity makes comparisons between studies difficult and could represent a substantial risk of bias (RoB) when it is not identified. Therefore, the present report aims to describe the development and background of a RoB assessment tool for caries diagnostic studies. The expert group developed and agreed to use a RoB assessment tool during three workshops. Here, existing instruments (e.g., QUADAS 2 and the Joanna Briggs Institute Reviewers' Manual) influenced the hierarchy and phrasing of the signalling questions that were adapted to the specific dental purpose. The tailored RoB assessment tool that was created consists of 16 signalling questions that are organized in four domains. This tool considers the selection/spectrum bias (1), the bias of the index (2) and reference tests (3), and the bias of the study flow and data analysis (4) and can be downloaded from the journal website. This paper explores possible sources of heterogeneity and bias in caries diagnostic studies and summarizes the relevant methodological aspects.

Indexed as

caries assessmentcaries detectioncaries diagnosticscaries monitoringclinical studieslaboratory studiesmethodologyreference standard

Identifiers

PMID34362007
PMCPMC8347423

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.