Evidence map›Paper›PMID 34362001›Full record

ArticleJournal of clinical medicine2021

Ossification and Fusion of the Vertebral Ring Apophysis as an Important Part of Spinal Maturation.

Lorenzo Costa, Steven de Reuver, Luc Kan, Peter Seevinck, Moyo C Kruyt, Tom P C Schlosser, René M Castelein

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Association of delayed apophyseal ring maturation with juvenile lumbar disc herniation: a retrospective case-control study with CT-based staging.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lorenzo CostaDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0001-9439-5186
Steven de ReuverDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0001-7319-8327
Luc KanDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Peter SeevinckDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Moyo C KruytDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Tom P C SchlosserDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0003-1517-5914
René M CasteleinDepartment of Orthopaedic Surgery, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.ORCID 0000-0002-6182-0315
University Medical Center Utrecht · NL

Funding

H2020 Marie Skłodowska-Curie Actions 801540
6 · The paper itself

Abstract

In scoliosis, most of the deformity is in the disc and occurs during the period of rapid growth. The ring apophyses form the insertion of the disc into the vertebral body, they then ossify and fuse to the vertebrae during that same crucial period. Although this must have important implications for the mechanical properties of the spine, relatively little is known of how this process takes place. This study describes the maturation pattern of the ring apophyses in the thoracic and lumbar spine during normal growth. High-resolution CT scans of the spine for indications not related to this study were included. Ossification and fusion of each ring apophysis from T1 to the sacrum was classified on midsagittal and midcoronal images (4 points per ring) by two observers. The ring apophysis maturation (RAM) was compared between different ages, sexes, and spinal levels. The RAM strongly correlated with age (R = 0.892,

Indexed as

fusionmaturationossificationring apophysisscoliosis

Identifiers

PMID34362001
PMCPMC8347734
OpenAlexW3185193880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.