Evidence map›Paper›PMID 34361986›Full record

ReviewJournal of clinical medicine2021

Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future.

Jo Nijs, Astrid Lahousse, Eleni Kapreli, Paraskevi Bilika, İsmail Saraçoğlu, Anneleen Malfliet, Iris Coppieters, Liesbet De Baets, Laurence Leysen, Eva Roose and 3 more

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 170 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730791 completednot on this map

Reliability and Validity of the IASP Clinical Criteria for Identifying Patients with Nociplastic Pain

Typeobservational_patient_registrySponsorUniversity of ThessalyRan2021 to 2024Enrolled94ConditionsChronic Pain, Central Sensitisation, Nociplastic PainArmsAlgo(s)rithm/ IASP clinical criteria, Pressure Pain Threshold
NCT05481710 completednot on this mapstarted 2022, after this paper: background citation

Investigation of the Profile of Patients With Chronic Shoulder Pain: A Cross-sectional Study

TypeobservationalSponsorParaskevi BilikaRan2022 to 2025Enrolled70ConditionsChronic Shoulder PainArmsNociplastic Pain Criteria
NCT06398132 completednot on this mapstarted 2024, after this paper: background citation

Thalidomide-Related Investigation on Understanding and Managing Pain for Thalidomide Survivors

TypeobservationalSponsorUniversity of NottinghamRan2024 to 2025Enrolled73ConditionsPain, Chronic, PainArmsUsual Care
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jo NijsPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0002-4976-6563
Astrid LahoussePain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0003-3967-8348
Eleni KapreliClinical Exercise Physiology & Rehabilitation Research Laboratory, Physiotherapy Department, Faculty of Health Sciences, University of Thessaly, 382 21 Lamia, Greece.
Paraskevi BilikaClinical Exercise Physiology & Rehabilitation Research Laboratory, Physiotherapy Department, Faculty of Health Sciences, University of Thessaly, 382 21 Lamia, Greece.ORCID 0000-0001-5469-6793
İsmail SaraçoğluKütahya Health Sciences University, Kütahya 43100, Turkey.ORCID 0000-0002-2621-2357
Anneleen MalflietPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0003-0598-7038
Iris CoppietersPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0003-1598-632X
Liesbet De BaetsPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Laurence LeysenPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Eva RoosePain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Jacqui ClarkPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Lennard VoogtPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Eva HuysmansPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0002-2571-6967

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, the International Association for the Study of Pain (IASP) released clinical criteria and a grading system for nociplastic pain affecting the musculoskeletal system. These criteria replaced the 2014 clinical criteria for predominant central sensitization (CS) pain and accounted for clinicians' need to identify (early) and correctly classify patients having chronic pain according to the pain phenotype. Still, clinicians and researchers can become confused by the multitude of terms and the variety of clinical criteria available. Therefore, this paper aims at (1) providing an overview of what preceded the IASP criteria for nociplastic pain ('the past'); (2) explaining the new IASP criteria for nociplastic pain in comparison with the 2014 clinical criteria for predominant CS pain ('the present'); and (3) highlighting key areas for future implementation and research work in this area ('the future'). It is explained that the 2021 IASP clinical criteria for nociplastic pain are in line with the 2014 clinical criteria for predominant CS pain but are more robust, comprehensive, better developed and hold more potential. Therefore, the 2021 IASP clinical criteria for nociplastic pain are important steps towards precision pain medicine, yet studies examining the clinimetric and psychometric properties of the criteria are urgently needed.

Indexed as

central sensitizationneuropathicnociceptivenociplastic painprecision medicine

Identifiers

PMID34361986
PMCPMC8347369

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.