Evidence map›Paper›PMID 34361953›Full record

ReviewMicroorganisms2021

Microbiological and Molecular Diagnosis of Mucormycosis: From Old to New.

Nina Lackner, Wilfried Posch, Cornelia Lass-Flörl

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Confronting the "lethal duo" in the ICU: early identification ofFrontiers in cellular and infection microbiology · 2026
    Observational
  8. Plasma Microbial Cell-free DNA Metagenomic Sequencing for Diagnosis of Invasive Fungal Diseases Among High-risk Outpatient and Inpatient Immunocompromised Hosts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  9. Article
  10. Article
  11. Detection ofJournal of clinical microbiology · 2025
    Article
  12. Article
  13. Case reports in pathology · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Recent Advances in Diagnostic Approaches for Mucormycosis.Journal of fungi (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nina LacknerDepartment of Hygiene and Medical Microbiology, Medical University Innsbruck, 6020 Innsbruck, Austria.
Wilfried PoschDepartment of Hygiene and Medical Microbiology, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-8955-7654
Cornelia Lass-FlörlDepartment of Hygiene and Medical Microbiology, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2946-7785
Innsbruck Medical University · AT

Funding

Christian Doppler Forschungsgesellschaft CD-Laboratory for Invasive Fungal Infections
6 · The paper itself

Abstract

Members of the order Mucorales may cause severe invasive fungal infections (mucormycosis) in immune-compromised and otherwise ill patients. Diagnosis of Mucorales infections and discrimination from other filamentous fungi are crucial for correct management. Here, we present an overview of current state-of-the-art mucormycosis diagnoses, with a focus on recent developments in the molecular field. Classical diagnostic methods comprise histology/microscopy as well as culture and are still the gold standard. Newer molecular methods are evolving quickly and display great potential in early diagnosis, although standardization is still missing. Among them, quantitative PCR assays with or without melt curve analysis are most widely used to detect fungal DNA in clinical samples. Depending on the respective assay, sequencing of the resulting PCR product can be necessary for genus or even species identification. Further, DNA-based methods include microarrays and PCR-ESI-MS. However, general laboratory standards are still in development, meaning that molecular methods are currently limited to add-on analytics to culture and microscopy.

Indexed as

clinical evaluationculturediagnosisDNAmicroscopyMucoralesPCRsensitivityspecificitystandardization

Identifiers

PMID34361953
PMCPMC8304313
OpenAlexW3185631697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.