Evidence map›Paper›PMID 34361789›Full record

ArticleMolecules (Basel, Switzerland)2021

Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter.

Anna Palko-Łabuz, Maria Błaszczyk, Kamila Środa-Pomianek, Olga Wesołowska

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Chalcones and Gastrointestinal Cancers: Experimental Evidence.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anna Palko-ŁabuzDepartment of Biophysics and Neuroscience, Wroclaw Medical University, ul. Chalubinskiego 3a, 50-368 Wroclaw, Poland.ORCID 0000-0002-4246-5717
Maria BłaszczykDepartment of Biophysics and Neuroscience, Wroclaw Medical University, ul. Chalubinskiego 3a, 50-368 Wroclaw, Poland.ORCID 0000-0001-9610-7598
Kamila Środa-PomianekDepartment of Biophysics and Neuroscience, Wroclaw Medical University, ul. Chalubinskiego 3a, 50-368 Wroclaw, Poland.ORCID 0000-0003-3454-5044
Olga WesołowskaDepartment of Biophysics and Neuroscience, Wroclaw Medical University, ul. Chalubinskiego 3a, 50-368 Wroclaw, Poland.ORCID 0000-0003-1659-3288
Wroclaw Medical University · PL

Funding

Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu SUB.A400.21.040
6 · The paper itself

Abstract

Isobavachalcone (IBC) is an active substance from the medicinal plant

Indexed as

AnimalsAntibiotics, AntineoplasticAntineoplastic Agents, PhytogenicATP Binding Cassette Transporter, Subfamily BBinding, CompetitiveCell Line, TumorChalconesDogsDoxorubicinDrug CombinationsDrug Resistance, NeoplasmGene ExpressionHT29 CellsHumansInhibitory Concentration 50Lipid BilayersABCB1 protein, humanAntibiotics, AntineoplasticAntineoplastic Agents, PhytogenicATP Binding Cassette Transporter, Subfamily BChalconesDoxorubicinDrug CombinationsisobavachalconeLipid BilayersMembranes, ArtificialPhosphatidylcholinesPlant ExtractsVerapamildifferential scanning calorimetry (DSC)isobavachalconeMDR1)model membranemolecular modelingmultidrug resistance (MDR)P-glycoprotein (ABCB1phospholipid bilayerprenylated chalcone

Identifiers

PMID34361789
PMCPMC8347294
OpenAlexW3188946651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.