Evidence map›Paper›PMID 34361736›Full record

ArticleMolecules (Basel, Switzerland)2021

A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice.

Eliav Blum, Raanan Margalit, Laura Levy, Tamar Getter, Ron Lahav, Sofia Zilber, Paul Bradfield, Beat A Imhof, Evgenia Alpert, Arie Gruzman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Eliav BlumDepartment of Chemistry, Faculty of Exact Sciences, Campus Ramat-Gan, Bar-Ilan University, Ramat-Gan 5290002, Israel.ORCID 0000-0003-1933-6367
Raanan MargalitScience in Action, 3 Pinchas Sapir Street, Weizmann Science Park, Ness-Ziona 7403650, Israel.
Laura LevyDepartment of Chemistry, Faculty of Exact Sciences, Campus Ramat-Gan, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Tamar GetterDepartment of Chemistry, Faculty of Exact Sciences, Campus Ramat-Gan, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Ron LahavAltA-ZuZ Therapeutics, 3 Pinchas Sapir Street, Weizmann Science Park, Ness-Ziona 7403650, Israel.
Sofia ZilberDepartment of Pathology, Shaare Zedek Medical Center, 12 Shmuel Bait Street, Jerusalem 9103102, Israel.
Paul BradfieldMesenFlow Technologies, Chemin des Aulx, 14, CH-1228 Geneva, Switzerland.
Beat A ImhofDepartment of Pathology and Immunology, University of Geneva, Rue Michel-Servet, CH-1211 Geneva, Switzerland.ORCID 0000-0002-6446-3990
Evgenia AlpertAltA-ZuZ Therapeutics, 3 Pinchas Sapir Street, Weizmann Science Park, Ness-Ziona 7403650, Israel.
Arie GruzmanDepartment of Chemistry, Faculty of Exact Sciences, Campus Ramat-Gan, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Bar-Ilan University · ILMicroflown Technologies (Netherlands) · NLShaare Zedek Medical Center · ILUniversity of Geneva · CH

Funding

Bar-Ilan University new faculty grant 182009
6 · The paper itself

Abstract

We recently developed a molecule (GT-73) that blocked leukocyte transendothelial migration from blood to the peripheral tissues, supposedly by affecting the platelet endothelial cell adhesion molecule (PECAM-1) function. GT-73 was tested in an LPS-induced acute respiratory distress syndrome (ARDS) mouse model. The rationale for this is based on the finding that the mortality of COVID-19 patients is partly caused by ARDS induced by a massive migration of leukocytes to the lungs. In addition, the role of

Indexed as

COVID-19 Drug TreatmentAnimalsCell AdhesionCell MovementCOVID-19Cytokine Release SyndromeCytokinesDisease Models, AnimalFemaleHumansLeukocytesLipopolysaccharidesMiceMice, Inbred BALB CPlatelet Endothelial Cell Adhesion Molecule-1PyrimidinesCytokinesLipopolysaccharidesPlatelet Endothelial Cell Adhesion Molecule-1PyrimidinesARDScovalent inhibitorcytokine stormleukocyte transmigrationPECAM-1

Identifiers

PMID34361736
PMCPMC8348436
OpenAlexW3184702809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.