Evidence map›Paper›PMID 34361681›Full record

ArticleMolecules (Basel, Switzerland)2021

Thermo- and pH-Responsive Gelatin/Polyphenolic Tannin/Graphene Oxide Hydrogels for Efficient Methylene Blue Delivery.

Ariel C de Oliveira, Paulo R Souza, Bruno H Vilsinski, Manuel E G Winkler, Marcos L Bruschi, Eduardo Radovanovic, Edvani C Muniz, Wilker Caetano, Artur J M Valente, Alessandro F Martins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Gels (Basel, Switzerland) · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ariel C de OliveiraGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.
Paulo R SouzaGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.
Bruno H VilsinskiGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.ORCID 0000-0002-9050-5760
Manuel E G WinklerGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.
Marcos L BruschiLaboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State Univesity of Maringá (UEM), 5970 Colombo Avenue, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-4838-5742
Eduardo RadovanovicDepartment of Chemistry, State University of Maringa, Maringá 87020-900, PR, Brazil.
Edvani C MunizGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.ORCID 0000-0001-6685-1519
Wilker CaetanoNúcleo de Pesquisas em Sistemas Fotodinâmicos, Chemistry Department, State University of Maringá, Maringá 87020-900, PR, Brazil.
Artur J M ValenteDepartment of Chemistry, CQC, University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0002-4612-7686
Alessandro F MartinsGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.ORCID 0000-0003-1002-3436

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico protocol 0008678964988973Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação para a Ciência e a Tecnologia UID/QUI/00313/2020
6 · The paper itself

Abstract

Gelatin (GE), amino-functionalized polyphenolic tannin derivative (TN), and graphene oxide (GO) were associated to yield thermo- and pH-responsive hydrogels for the first time. Durable hydrogel assemblies for drug delivery purposes were developed using the photosensitizer methylene blue (MB) as a drug model. The cooling GE/TN blends provide brittle physical assemblies. To overcome this disadvantage, different GO contents (between 0.31% and 1.02%

Indexed as

Transition TemperatureBiocompatible MaterialsDiffusionDrug Delivery SystemsDrug LiberationElastic ModulusGelatinGraphiteHydrogelsHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsMethylene BluePhase TransitionPorosityTanninsBiocompatible MaterialsGelatingraphene oxideGraphiteHydrogelsMethylene BlueTanninscondensed tanninsdrug delivery systemsphysical hydrogels

Identifiers

PMID34361681
PMCPMC8347097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.