Evidence map›Paper›PMID 34361678›Full record

ReviewMolecules (Basel, Switzerland)2021

Amperometric Biosensors Based on Direct Electron Transfer Enzymes.

Franziska Schachinger, Hucheng Chang, Stefan Scheiblbrandner, Roland Ludwig

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Electrocatalytic MnMolecules (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. FlavocytochromeBiosensors · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Franziska SchachingerBiocatalysis and Biosensing Laboratory, Department of Food Sciences and Technology, BOKU-University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Hucheng ChangBiocatalysis and Biosensing Laboratory, Department of Food Sciences and Technology, BOKU-University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0003-0705-1081
Stefan ScheiblbrandnerBiocatalysis and Biosensing Laboratory, Department of Food Sciences and Technology, BOKU-University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0002-9858-1637
Roland LudwigBiocatalysis and Biosensing Laboratory, Department of Food Sciences and Technology, BOKU-University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0002-5058-5874

Funding

Austrian Science Fund FWF P 31019Austrian Science Fund FWF W 1224European Research Council 726396
6 · The paper itself

Abstract

The accurate determination of analyte concentrations with selective, fast, and robust methods is the key for process control, product analysis, environmental compliance, and medical applications. Enzyme-based biosensors meet these requirements to a high degree and can be operated with simple, cost efficient, and easy to use devices. This review focuses on enzymes capable of direct electron transfer (DET) to electrodes and also the electrode materials which can enable or enhance the DET type bioelectrocatalysis. It presents amperometric biosensors for the quantification of important medical, technical, and environmental analytes and it carves out the requirements for enzymes and electrode materials in DET-based third generation biosensors. This review critically surveys enzymes and biosensors for which DET has been reported. Single- or multi-cofactor enzymes featuring copper centers, hemes, FAD, FMN, or PQQ as prosthetic groups as well as fusion enzymes are presented. Nanomaterials, nanostructured electrodes, chemical surface modifications, and protein immobilization strategies are reviewed for their ability to support direct electrochemistry of enzymes. The combination of both biosensor elements-enzymes and electrodes-is evaluated by comparison of substrate specificity, current density, sensitivity, and the range of detection.

Indexed as

ElectrodesElectronsBiocatalysisBiological MonitoringBiomarkers, TumorBiosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringCoenzymesElectrochemistryElectron TransportEnzymes, ImmobilizedMolecular StructureNanostructuresBiomarkers, TumorBlood GlucoseCoenzymesEnzymes, Immobilizedbiosensorcurrent densitydirect electron transferenzymenanocompositenanomaterialnanoparticleselectivityself-assembled monolayerssensitivity

Identifiers

PMID34361678
PMCPMC8348568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.