Evidence map›Paper›PMID 34361646›Full record

ArticleMolecules (Basel, Switzerland)2021

Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion.

Eric Ofosu Kissi, Robin Nilsson, Liebert Parreiras Nogueira, Anette Larsson, Ingunn Tho

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric Ofosu KissiDepartment of Pharmacy, University of Oslo, P.O. Box, 1068 Blindern, 0316 Oslo, Norway.ORCID 0000-0001-9301-9939
Robin NilssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivagen 10, 41296 Gothenburg, Sweden.
Liebert Parreiras NogueiraDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, P.O. Box, 1109 Blindern, 0317 Oslo, Norway.ORCID 0000-0002-7767-464X
Anette LarssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivagen 10, 41296 Gothenburg, Sweden.ORCID 0000-0002-6119-8423
Ingunn ThoDepartment of Pharmacy, University of Oslo, P.O. Box, 1068 Blindern, 0316 Oslo, Norway.ORCID 0000-0003-4241-4183

Funding

NordForsk 85352
6 · The paper itself

Abstract

Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final product. The aim of this study was to investigate the influence of the drug load on printability and physical stability. The poor glass former naproxen (NAP) was hot-melt extruded with Kollidon

Indexed as

Drug LiberationPrinting, Three-DimensionalExcipientsNaproxenSolubilityTabletsTechnology, PharmaceuticalTemperatureExcipientsNaproxenTablets3D printingadditive manufacturingfused deposition modellingglass solutionhot-melt extrusionX-ray computed microtomography

Identifiers

PMID34361646
PMCPMC8347219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.