Evidence map›Paper›PMID 34361641›Full record

ArticleMolecules (Basel, Switzerland)2021

Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis.

Aboagye Kwarteng Dofuor, Temitayo Samson Ademolue, Cynthia Mmalebna Amisigo, Kwaku Kyeremeh, Theresa Manful Gwira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aboagye Kwarteng DofuorWest African Center for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.ORCID 0000-0002-4712-5244
Temitayo Samson AdemolueWest African Center for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.ORCID 0000-0002-4400-3364
Cynthia Mmalebna AmisigoWest African Center for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.ORCID 0000-0002-4120-5139
Kwaku KyeremehDepartment of Chemistry, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana.ORCID 0000-0002-3644-9497
Theresa Manful GwiraWest African Center for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.ORCID 0000-0002-6725-7965

Funding

DELTAS Africa grant (DEL-15-007: Awandare)World Bank African Centres of Excellence grant (ACE02-WACCBIP: Awandare)
6 · The paper itself

Abstract

The search for novel antitrypanosomals and the investigation into their mode of action remain crucial due to the toxicity and resistance of commercially available antitrypanosomal drugs. In this study, two novel antitrypanosomals, tortodofuordioxamide (compound

Indexed as

Trypanocidal AgentsAnimalsMiceRAW 264.7 CellsTrypanosoma brucei bruceiTrypanosomiasis, AfricanTrypanocidal AgentsantitrypanosomaltortodofuordioxamidetortodofuorpyramidetortozanthoxylamideTrypanosoma bruceiZ. zanthoxyloides

Identifiers

PMID34361641
PMCPMC8347361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.