ArticleMolecules (Basel, Switzerland)2021
Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- NaphthaleneACS omega · 2025Article
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- Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.Molecules (Basel, Switzerland) · 2023Review
- Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(spACS omega · 2023Article
- Selenylated Imidazo[1,2Molecules (Basel, Switzerland) · 2023Article
- Versatile Electrochemical Synthesis of Selenylbenzo[Frontiers in chemistry · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-nitroaromatic halides (Cl, Br, I). These diselenides present GPx-mimetic properties, showing better antioxidant activity than the standard GPx-mimetic compounds, ebselen and diphenyl diselenide. DFT analysis demonstrated that the electronic properties of the substituents determine the charge delocalization and the partial charge on selenium, which correlate with the catalytic performances. The amino group concurs in the stabilization of the selenolate intermediate through a hydrogen bond with the selenium.
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