Evidence map›Paper›PMID 34361587›Full record

ArticleMolecules (Basel, Switzerland)2021

The Highly Regioselective Synthesis of Novel Imidazolidin-2-Ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity.

Almir S Gazizov, Andrey V Smolobochkin, Elizaveta A Kuznetsova, Dinara S Abdullaeva, Alexander R Burilov, Michail A Pudovik, Alexandra D Voloshina, Victor V Syakaev, Anna P Lyubina, Syumbelya K Amerhanova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. TsCl/DBU-Mediated COChemistry, an Asian journal · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Almir S GazizovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.ORCID 0000-0001-9899-9606
Andrey V SmolobochkinArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.ORCID 0000-0002-1470-8136
Elizaveta A KuznetsovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Dinara S AbdullaevaChemistry Department, Kazan Federal University, Kremlyovskaya Str. 18, 420008 Kazan, Russia.
Alexander R BurilovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Michail A PudovikArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Alexandra D VoloshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Victor V SyakaevArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Anna P LyubinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Syumbelya K AmerhanovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova Str. 8, 420088 Kazan, Russia.
Julia K VoroninaN.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Ave. 31, 119991 Moscow, Russia.ORCID 0000-0001-9222-5853

Funding

Russian Science Foundation 21-73-20020
6 · The paper itself

Abstract

A series of novel 4-(het)arylimidazoldin-2-ones were obtained by the acid-catalyzed reaction of (2,2-diethoxyethyl)ureas with aromatic and heterocyclic

Indexed as

Antineoplastic AgentsCyclizationHeLa CellsHumansImidazolidinesAntineoplastic Agentsethylene ureaImidazolidinesanti-cancer activityanti-tumor activitycyclizationcytotoxicityimidazolidine-2-oneregioselectivityurea

Identifiers

PMID34361587
PMCPMC8347191

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.