ReviewMolecules (Basel, Switzerland)2021
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Skin Aging and Carotenoids: A Systematic Review of Their Multifaceted Protective Mechanisms.Nutrients · 2025Pooled it
- Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.Journal of cosmetic dermatology · 2025Pooled it
- Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study.Lasers in medical science · 2026Trial
- Efficacy of 1064-Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi-Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study.Journal of cosmetic dermatology · 2026Trial
- Comparison of injectable platelet-rich fibrin, titanium platelet-rich fibrin, and 0.8% hyaluronic acid applications versus periodontal dressing alone in wound healing after gingivectomy and gingivoplasty operations: randomized controlled clinical study.Clinical oral investigations · 2026Trial
- Effect of topical application of atorvastatin gel versus hyaluronic acid on immediate loading dental implant in posterior maxilla: a randomized controlled trial.BMC oral health · 2026Trial
- Benefits of a Multifunctional Sunscreen Formulation Containing Nanoencapsulated Antioxidants in the Skin Protection Against UV Radiation and Blue Light: Clinical and Preclinical Studies.Journal of cosmetic dermatology · 2025Trial
- Safety and Efficacy of a "High and Low Molecular Weight Hyaluronic Acid Hybrid Complex" Injection for Face Rejuvenation.Journal of cosmetic dermatology · 2025Trial
- High molecular weight hyaluronic acid vectorised with clay provides long-term hydration and reduces skin brightness.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Trial
- The Moisturizing Efficacy of a Proprietary Dermo-Cosmetic Product( CLS02021) Versus Placebo in a 4-week Application Period.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Trial
- Comparing the Cutaneous Impacts of a Topical Restructuring Serum versus. Injected Hyaluronic Acid (HA) and Their Combination as Potential Anti-Aging Strategies in Chinese Women: An In Vivo Study.Dermatology and therapy · 2026Article
- Penetration enhancement effects of topically applied crosslinked hyaluronic acid.International journal of cosmetic science · 2026Article
- Hydrogel facial mask for sensitive skin: A pilot study of long-term effects on hydration, barrier function and mechanical properties.International journal of cosmetic science · 2026Article
- Natural Polymer-Based Hemostatic Hydrogels with Advanced Material and Structural Designs for Functional Applications.Pharmaceutics · 2026Review
- Promising Natural Polymer-Based Dressings for Diabetic Foot Ulcers: Mechanisms, Preclinical Studies, and Clinical Applications.Pharmaceutics · 2026Review
- Smart Release of the Antioxidant from Chitosan-Hyaluronan Reservoir in Skin Wound Healing.Pharmaceutics · 2026Review
- Hydration-stable PVA-based skin phantom for wearable biopotential sensor evaluation.Scientific reports · 2026Article
- Preparation and Investigation ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Review
- Hyaluronic Acid-like Skin Plumping and Radiance Benefits of aMarine drugs · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.