Evidence map›Paper›PMID 34361563›Full record

ArticleMolecules (Basel, Switzerland)2021

Bioactive Compounds from Lemon (

Valeria Sorrenti, Valeria Consoli, Salvo Grosso, Marco Raffaele, Margherita Amenta, Gabriele Ballistreri, Simona Fabroni, Paolo Rapisarda, Luca Vanella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Beneficial Effects ofJournal of obesity · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Valeria SorrentiDepartment of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5973-1495
Valeria ConsoliDepartment of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-8961-5818
Salvo GrossoDepartment of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
Marco RaffaeleDepartment of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
Margherita AmentaCouncil for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.ORCID 0000-0002-4415-8470
Gabriele BallistreriCouncil for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.ORCID 0000-0002-1835-0047
Simona FabroniCouncil for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.ORCID 0000-0002-2567-6838
Paolo RapisardaCouncil for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.
Luca VanellaDepartment of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-6314-6029
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The consumption of plant-based food is important for health promotion, especially regarding the prevention and management of chronic diseases such as diabetes. We investigated the effects of a lemon extract (LE), containing ≥20.0% total flavanones and ≥1.0% total hydroxycinnamic acids, on insulin signaling in murine 3T3-L1 adipocytes treated with TNF-α, which was used to mimic in vitro the insulin resistance condition that characterizes diabetes mellitus. Our results showed LE increased PPARγ, GLUT4 and DGAT-1 levels, demonstrating the potential of this lemon extract in the management of insulin resistance conditions associated with TNF-α pathway activation. LE treatment further decreased the release of interleukin 6 (IL-6) and restored triglyceride synthesis, which is the main feature of a healthy adipocyte.

Indexed as

Insulin ResistancePhytochemicalsPlant Extracts3T3-L1 CellsAdipocytesAnimalsCitrusMiceTumor Necrosis Factor-alphaPhytochemicalsPlant ExtractsTumor Necrosis Factor-alphaadipocytesinsulin resistancelemon extractpolyphenols

Identifiers

PMID34361563
PMCPMC8347189
OpenAlexW3183280173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.