Advances and Novel Perspectives on Colloids, Hydrogels, and Aerogels Based on Coordination Bonds with Biological Interest Ligands.

This perspective article shows new advances in the synthesis of colloids, gels, and aerogels generated by combining metal ions and ligands of biological interest, such as nucleobases, nucleotides, peptides, or amino acids, among other derivatives. The characteristic dynamism of coordination bonds between metal center and biocompatible-type ligands, together with molecular recognition capability of these ligands, are crucial to form colloids and gels. These supramolecular structures are generated by forming weak van der Waals bonds such as hydrogen bonds or π-π stacking between the aromatic rings. Most gels are made up of nano-sized fibrillar networks, although their morphologies can be tuned depending on the synthetic conditions. These new materials respond to different stimuli such as pH, stirring, pressure, temperature, the presence of solvents, among others. For these reasons, they can trap and release molecules or metal ions in a controlled way allowing their application in drug delivery as antimicrobial and self-healable materials or sensors. In addition, the correct selection of the metal ion enables to build catalytic or luminescent metal-organic gels. Even recently, the use of these colloids as 3D-dimensional printable inks has been published. The elimination of the solvent trapped in the gels allows the transformation of these into metal-organic aerogels (MOAs) and metal-organic xerogels (MOXs), increasing the number of possible applications by generating new porous materials and composites useful in adsorption, conversion, and energy storage. The examples shown in this work allow us to visualize the current interest in this new type of material and their perspectives in the short-medium term. Furthermore, these investigations show that there is still a lot of work to be done, opening the door to new and interesting applications.