ArticleNanomaterials (Basel, Switzerland)2021
Gold Nanoparticle DNA Damage by Photon Beam in a Magnetic Field: A Monte Carlo Study.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Gold Nanoparticle-Mediated DNA Damage Under FLASH Electron-Beam Irradiation: A Monte Carlo Study.Nanomaterials (Basel, Switzerland) · 2026Article
- Reactive Oxygen Species Yield near Gold Nanoparticles Under Ultrahigh-Dose-Rate Electron Beams: A Monte Carlo Study.Nanomaterials (Basel, Switzerland) · 2025Article
- Do cell culturing influence the radiosensitizing effect of gold nanoparticles: a Monte Carlo study.EJNMMI physics · 2025Article
- Exploring the Frontier of Biopolymer-Assisted Drug Delivery: Advancements, Clinical Applications, and Future Perspectives in Cancer Nanomedicine.Drug design, development and therapy · 2024Review
- Review of nanomaterial advances for ionizing radiation dosimetry.Applied physics reviews · 2023Review
- The Refined Application and Evolution of Nanotechnology in Enhancing Radiosensitivity During Radiotherapy: Transitioning from Gold Nanoparticles to Multifunctional Nanomaterials.International journal of nanomedicine · 2023Review
- Dosimetric Impact on the Flattening Filter and Addition of Gold Nanoparticles in Radiotherapy: A Monte Carlo Study on Depth Dose Using the 6 and 10 MV FFF Photon Beams.Materials (Basel, Switzerland) · 2022Article
- Evaluation of Dosimetric Effect of Bone Scatter on Nanoparticle-Enhanced Orthovoltage Radiotherapy: A Monte Carlo Phantom Study.Nanomaterials (Basel, Switzerland) · 2022Article
- Neuroprotective Effect of Gold Nanoparticles and Alpha-Lipoic Acid Mixture against Radiation-Induced Brain Damage in Rats.International journal of molecular sciences · 2022Article
- Special Issue: Application of Nanomaterials in Biomedical Imaging and Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2022Article
- Integration of an Independent Monitor Unit Check for High-Magnetic-Field MR-Guided Radiation Therapy System.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ever since the emergence of magnetic resonance (MR)-guided radiotherapy, it is important to investigate the impact of the magnetic field on the dose enhancement in deoxyribonucleic acid (DNA), when gold nanoparticles are used as radiosensitizers during radiotherapy. Gold nanoparticle-enhanced radiotherapy is known to enhance the dose deposition in the DNA, resulting in a double-strand break. In this study, the effects of the magnetic field on the dose enhancement factor (DER) for varying gold nanoparticle sizes, photon beam energies and magnetic field strengths and orientations were investigated using Geant4-DNA Monte Carlo simulations. Using a Monte Carlo model including a single gold nanoparticle with a photon beam source and DNA molecule on the left and right, it is demonstrated that as the gold nanoparticle size increased, the DER increased. However, as the photon beam energy decreased, an increase in the DER was detected. When a magnetic field was added to the simulation model, the DER was found to increase by 2.5-5% as different field strengths (0-2 T) and orientations (x-, y- and z-axis) were used for a 100 nm gold nanoparticle using a 50 keV photon beam. The DNA damage reflected by the DER increased slightly with the presence of the magnetic field. However, variations in the magnetic field strength and orientation did not change the DER significantly.
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