Evidence map›Paper›PMID 34361098›Full record

ArticleInternational journal of molecular sciences2021

Synthesis and Characterization of New Biodegradable Injectable Thermosensitive Smart Hydrogels for 5-Fluorouracil Delivery.

Adam Kasiński, Monika Zielińska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka, Marcin Sobczak

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  8. Review
  9. ROS- and pH-Responsive Polydopamine Functionalized TiNanomaterials (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adam KasińskiDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.ORCID 0000-0003-0187-9638
Monika Zielińska-PisklakDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.
Sebastian KowalczykFaculty of Chemistry, Warsaw University of Technology, 3 Noakowskiego Str., 00-664 Warsaw, Poland.ORCID 0000-0002-9372-3122
Andrzej PlichtaFaculty of Chemistry, Warsaw University of Technology, 3 Noakowskiego Str., 00-664 Warsaw, Poland.ORCID 0000-0002-4935-2627
Anna ZgadzajDepartment of Environmental Health Sciences, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.ORCID 0000-0001-5121-3530
Ewa OledzkaDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.
Marcin SobczakDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.ORCID 0000-0002-7362-8881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, injectable, thermosensitive smart hydrogel local drug delivery systems (LDDSs) releasing the model antitumour drug 5-fluorouracil (5-FU) were developed. The systems were based on biodegradable triblock copolymers synthesized via ring opening polymerization (ROP) of ε-caprolactone (CL) in the presence of poly(ethylene glycol) (PEG) and zirconium(IV) acetylacetonate (Zr(acac)

Indexed as

Drug Delivery SystemsTemperatureAnimalsAntimetabolites, AntineoplasticBiocompatible MaterialsCell ProliferationCells, CulturedFibroblastsFluorouracilHydrogelsMiceAntimetabolites, AntineoplasticBiocompatible MaterialsFluorouracilHydrogelsantitumor drug delivery systemsbiomedical hydrogelslocal drug delivery systemssmart hydrogelsε-caprolactone and poly(ethylene glycol) copolymers

Identifiers

PMID34361098
PMCPMC8347305

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.