Evidence map›Paper›PMID 34361094›Full record

ArticleInternational journal of molecular sciences2021

Evidence for Protein-Protein Interaction between Dopamine Receptors and the G Protein-Coupled Receptor 143.

Beatriz Bueschbell, Prashiela Manga, Erika Penner, Anke C Schiedel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Beatriz BueschbellCenter for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0001-6777-0032
Prashiela MangaRonald O. Perelman Department of Dermatology, Grossman School of Medicine, New York University, New York, NY 10016, USA.
Erika PennerDepartment of Pharmaceutical & Medicinal Chemistry, Pharmaceutical Institute, University of Bonn, D-53121 Bonn, Germany.
Anke C SchiedelDepartment of Pharmaceutical & Medicinal Chemistry, Pharmaceutical Institute, University of Bonn, D-53121 Bonn, Germany.ORCID 0000-0002-8114-3139
University of Bonn · DENew York University · USUniversity of Coimbra · PT

Funding

FCT SFRH/BD/149709/2019
6 · The paper itself

Abstract

Protein-protein interactions between G protein-coupled receptors (GPCRs) can augment their functionality and increase the repertoire of signaling pathways they regulate. New therapeutics designed to modulate such interactions may allow for targeting of a specific GPCR activity, thus reducing potential for side effects. Dopamine receptor (DR) heteromers are promising candidates for targeted therapy of neurological conditions such as Parkinson's disease since current treatments can have severe side effects. To facilitate development of such therapies, it is necessary to identify the various DR binding partners. We report here a new interaction partner for DRD

Indexed as

Protein Interaction Domains and Motifsbeta-ArrestinsDopamineEye ProteinsHumansMembrane GlycoproteinsMutationProtein BindingReceptors, Dopamine D2Receptors, Dopamine D3Signal Transductionbeta-ArrestinsDopamineDRD2 protein, humanDRD3 protein, humanEye ProteinsGPR143 protein, humanMembrane GlycoproteinsReceptors, Dopamine D2Receptors, Dopamine D3dopamine receptorsDRD2DRD3GPR143Parkinson’s disease

Identifiers

PMID34361094
PMCPMC8348196
OpenAlexW3190404262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.