ReviewInternational journal of molecular sciences2021
The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- MAC5A dual-functionally regulates cold responses at both transcriptional and post-transcriptional levels.Journal of advanced research · 2026Article
- Population Genomics of Almond (Prunus dulcis) Reveals Region-Specific Selection and a Complex History of Domestication.Molecular ecology · 2026Article
- Lysine acetylome analysis reveals the critical role of acetylation-modified transcription factors and a chaperone protein in regulation of salt tolerance in Tamarix hispida.BMC plant biology · 2026Article
- Genome-Wide Identification, Expression and Tissue-Specific Epigenetic Modification Analysis of theBiology · 2026Article
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- Quantitative trait loci associated with drought stress tolerance in wheat primed with zinc oxide nanoparticles at seed germination and seedling stages.Scientific reports · 2026Article
- Genome-Wide Identification and Characterization of C3H-ZFP Genes and Their Expression Under Salt and Cadmium Stress Conditions in Soybean.Current issues in molecular biology · 2026Article
- Zinc finger proteins (ZFPs) in health and disease.Molecular biomedicine · 2026Review
- Identification of genetic loci and domestication gene GmZFP1 associated with soybean hypocotyl elongation in seedling stage by genome-wide association study.BMC plant biology · 2026Article
- Transcriptional regulation modulates nitrate uptake and utilization ofFrontiers in plant science · 2026Article
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- The C3H zinc finger gene family in tartary buckwheat: genome-wide characterization, evolution, and a specialized role in salt stress response.Frontiers in plant science · 2026Article
- Identification of novel major quantitative trait loci associated with selenium and zinc accumulation inFrontiers in plant science · 2026Article
- Genome-wide identification and expression analysis of CFrontiers in plant science · 2026Article
- The non-tandem CCCH zinc finger protein AtC3H26 modulates salt stress response and phosphate starvation response through its ribonuclease activity in Arabidopsis.BMC plant biology · 2025Article
- Genetic mapping of a chickpea (Cicer arietinum L.) diversity panel for mineral biofortification towards human nutrition.The plant genome · 2025Article
- Article
- A multi-parent population approach to reveal the genetic basis of plant height in maize.BMC plant biology · 2025Article
- Rice Transcription Factor HSTL Regulates Plant Height and Salt Stress Response by Modulating Gibberellin Homeostasis.Rice (New York, N.Y.) · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Zinc-finger proteins, a superfamily of proteins with a typical structural domain that coordinates a zinc ion and binds nucleic acids, participate in the regulation of growth, development, and stress adaptation in plants. Most zinc fingers are C2H2-type or CCCC-type, named after the configuration of cysteine (C) and histidine (H); the less-common CCCH zinc-finger proteins are important in the regulation of plant stress responses. In this review, we introduce the domain structures, classification, and subcellular localization of CCCH zinc-finger proteins in plants and discuss their functions in transcriptional and post-transcriptional regulation via interactions with DNA, RNA, and other proteins. We describe the functions of CCCH zinc-finger proteins in plant development and tolerance to abiotic stresses such as salt, drought, flooding, cold temperatures and oxidative stress. Finally, we summarize the signal transduction pathways and regulatory networks of CCCH zinc-finger proteins in their responses to abiotic stress. CCCH zinc-finger proteins regulate the adaptation of plants to abiotic stress in various ways, but the specific molecular mechanisms need to be further explored, along with other mechanisms such as cytoplasm-to-nucleus shuttling and post-transcriptional regulation. Unraveling the molecular mechanisms by which CCCH zinc-finger proteins improve stress tolerance will facilitate the breeding and genetic engineering of crops with improved traits.
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