Evidence map›Paper›PMID 34361074›Full record

ArticleInternational journal of molecular sciences2021

Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies.

Abdullah Al Mamun, Filip Pidaný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Monika Schmidt, Maria Carmen Catapano, Martina Hrabinová, Daniel Jun, Lubica Múčková and 9 more

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Alkaloids from In Vitro CulturedPlants (Basel, Switzerland) · 2026
    Article
  2. Synthesis, Characterization, and Biological Evaluation ofMolecules (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Abdullah Al MamunADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-3441-8814
Filip PidanýADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0003-1167-3959
Daniela HulcováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Jana MaříkováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-9758-2067
Tomáš KučeraDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0001-6650-1738
Monika SchmidtDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanského 62, 500 03 Hradec Králové, Czech Republic.ORCID 0000-0003-4984-9155
Maria Carmen CatapanoDepartment of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-2850-7458
Martina HrabinováDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0002-9428-4109
Daniel JunDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0002-0882-6304
Lubica MúčkováDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0001-6693-6061
Jiří KunešDepartment of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Jiří JanoušekDepartment of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-3336-3874
Rudolf AndrýsDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanského 62, 500 03 Hradec Králové, Czech Republic.
Lucie NovákováDepartment of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0003-3570-5871
Rozálie PeřinováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Negar MaafiADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-4227-7855
Ondřej SoukupDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0001-6376-8701
Jan KorábečnýDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0001-6977-7596
Lucie CahlíkováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-1555-8870
Charles University · CZUniversity Hospital Hradec Králové · CZUniversity of Defence · CZUniversity of Hradec Králové · CZ

Funding

CERIT Scientific Cloud LM2015085CESNET LM2015042Czech Science Foundation 20-29633JMICU SAF2016-76693-RMinisterstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_019/0000841Univerzita Hradec Králové VT2019-2021Univerzita Karlova v Praze SVV UK 260 548, 260 547; Progres/UK Q42
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the

Indexed as

Molecular Docking SimulationAcetylcholinesteraseAmaryllidaceae AlkaloidsButyrylcholinesteraseCell ProliferationCholinesterase InhibitorsComputer SimulationHumansNeuroblastomaStructure-Activity RelationshipTumor Cells, CulturedTyramineAcetylcholinesteraseAmaryllidaceae AlkaloidsButyrylcholinesteraseCholinesterase InhibitorsnorbelladineTyramineAlzheimer’s diseaseamaryllidaceae alkaloidbutyrylcholinesterasedocking studiesnorbelladine-type

Identifiers

PMID34361074
PMCPMC8348983
OpenAlexW3192212527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.