Evidence map›Paper›PMID 34361070›Full record

ArticleInternational journal of molecular sciences2021

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines.

Kazuo Tomita, Taisuke Nagasawa, Yoshikazu Kuwahara, Seiji Torii, Kento Igarashi, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Akihiro Kurimasa, Tomoaki Sato

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  6. Article
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  8. Ferroptosis is an effective strategy for cancer therapy.Medical oncology (Northwood, London, England) · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. The interplay of miRNAs and ferroptosis in diseases related to iron overload.Apoptosis : an international journal on programmed cell death · 2024
    Review
  13. Review
  14. Review
  15. Review
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  17. Regulation of mCell death discovery · 2023
    Review
  18. The Regulation of Ferroptosis by Noncoding RNAs.International journal of molecular sciences · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kazuo TomitaDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.
Taisuke NagasawaDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.
Yoshikazu KuwaharaDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.
Seiji ToriiCenter for Food Science and Wellness, Gunma University, Maebashi-City 371-8510, Gunma, Japan.
Kento IgarashiDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.
Mehryar Habibi RoudkenarDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.
Amaneh Mohammadi RoushandehDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.
Akihiro KurimasaDivision of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai-City 983-8536, Miyagi, Japan.
Tomoaki SatoDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-City 890-8544, Kagoshima, Japan.ORCID 0000-0001-9147-396X
Kagoshima University · JPGunma University · JPTohoku Medical and Pharmaceutical University · JP

Funding

Japan Society for the Promotion of Science 19K10318
6 · The paper itself

Abstract

In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) cells that can survive over 30 days after 2 Gy/day X-ray exposures. These cells also show resistance to anticancer agents and hydrogen peroxide (H

Indexed as

FerroptosisGene Expression Regulation, NeoplasticRadiation ToleranceArachidonate 12-LipoxygenaseHeLa CellsHumansHydrogen PeroxideMembrane Potential, MitochondrialMicroRNAsMouth NeoplasmsReactive Oxygen SpeciesSignal TransductionTumor Cells, CulturedALOX12 protein, humanArachidonate 12-LipoxygenaseHydrogen PeroxideMicroRNAsMIRN7-1 microRNA, humanReactive Oxygen SpeciesALOX12clinically relevant radioresistant (CRR) cellsFe2+ferroptosismicroRNAreactive oxygen species (ROS)

Identifiers

PMID34361070
PMCPMC8348045
OpenAlexW3192539705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.