Evidence map›Paper›PMID 34361060›Full record

ArticleInternational journal of molecular sciences2021

Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.

Davide De Biase, Valeria Valente, Andrea Conte, Francesca Cammarota, Nicola Boccella, Lucia D'Esposito, Ilaria d'Aquino, Orlando Paciello, Simona Paladino, Giovanna Maria Pierantoni

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. HIPK2 in the physiology of nervous system and its implications in neurological disorders.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Davide De BiaseDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-8118-9807
Valeria ValenteDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Andrea ConteDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Francesca CammarotaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Nicola BoccellaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Lucia D'EspositoCentro Servizi Veterinari, University of Naples Federico II, 80131 Naples, Italy.
Ilaria d'AquinoDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.
Orlando PacielloDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.
Simona PaladinoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-5332-6774
Giovanna Maria PierantoniDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that phosphorylates various transcriptional and chromatin regulators, thus modulating numerous important cellular processes, such as proliferation, apoptosis, DNA damage response, and oxidative stress. The role of HIPK2 in the pathogenesis of cancer and fibrosis is well established, and evidence of its involvement in the homeostasis of multiple organs has been recently emerging. We have previously demonstrated that

Indexed as

AnimalsCentral Nervous SystemFemaleFibrosisHMGA ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMyocardiumNeuronsPhenotypePhosphorylationProtein Serine-Threonine KinasesHipk2 protein, mouseHMGA ProteinsProtein Serine-Threonine KinasesHIPK2knock-out micemyopathic changes

Identifiers

PMID34361060
PMCPMC8348407
OpenAlexW3192400578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.