Evidence map›Paper›PMID 34361003›Full record

ArticleInternational journal of molecular sciences2021

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.

Chung-Chi Yang, Yen-Ling Hung, Wen-Chin Ko, Yi-Ju Tsai, Jia-Feng Chang, Cher-Wei Liang, Der-Chen Chang, Chi-Feng Hung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
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  4. Protective effect ofVeterinarni medicina · 2026
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  8. Extracellular vesicles ofGut microbes · 2025
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  10. Detection of Anaphylaxis Through the Cutaneous Barrier.Current allergy and asthma reports · 2025
    Review
  11. Review
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  15. Review
  16. Review
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  18. Article
  19. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chung-Chi YangDivision of Cardiovascular Medicine, Taoyuan Armed Forces General Hospital, Taoyuan City 32551, Taiwan.
Yen-Ling HungGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Wen-Chin KoSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Yi-Ju TsaiGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Jia-Feng ChangDepartment of Internal Medicine, Division of Nephrology, En Chu Kong Hospital, New Taipei City 23702, Taiwan.
Cher-Wei LiangSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0002-9903-7473
Der-Chen ChangDepartment of Mathematics and Statistics and Department of Computer Science, Georgetown University, Washington, DC 20057, USA.
Chi-Feng HungSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0003-3478-5451
Fu Jen Catholic University · TWEn Chu Kong Hospital · TWGeorgetown University · USTaoyuan Armed Forces General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic and persistent inflammatory skin disease characterized by eczematous lesions and itching, and it has become a serious health problem. However, the common clinical treatments provide limited relief and are accompanied by adverse effects. Therefore, there is a need to develop novel and effective therapies to treat AD. Neferine is a small molecule compound isolated from the green embryo of the mature seeds of lotus (

Indexed as

AnimalsAnti-Inflammatory AgentsBenzylisoquinolinesDermatitis, AtopicDinitrochlorobenzeneHaCaT CellsHumansInterferon-gammaMAP Kinase Signaling SystemMiceMice, Inbred BALB CNF-kappa BTumor Necrosis Factor-alphaAnti-Inflammatory AgentsBenzylisoquinolinesDinitrochlorobenzeneInterferon-gammaneferineNF-kappa BTumor Necrosis Factor-alphaatopic dermatitiskeratinocytesMAPKnatural productneferineNF-κB

Identifiers

PMID34361003
PMCPMC8348662
OpenAlexW3190612834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.