Evidence map›Paper›PMID 34360997›Full record

ReviewInternational journal of molecular sciences2021

The Active Mechanism of Nucleosome Depletion by Poly(dA:dT) Tracts In Vivo.

Toby Barnes, Philipp Korber

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Nucleosome Remodeling at the YeastInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Toby BarnesBiomedical Center (BMC), Divison of Molecular Biology, Faculty of Medicine, LMU Munich, 82152 Munich, Germany.
Philipp KorberBiomedical Center (BMC), Divison of Molecular Biology, Faculty of Medicine, LMU Munich, 82152 Munich, Germany.
Ludwig-Maximilians-Universität München · DE

Funding

German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) SFB1064
6 · The paper itself

Abstract

Poly(dA:dT) tracts cause nucleosome depletion in many species, e.g., at promoters and replication origins. Their intrinsic biophysical sequence properties make them stiff and unfavorable for nucleosome assembly, as probed by in vitro nucleosome reconstitution. The mere correlation between nucleosome depletion over poly(dA:dT) tracts in in vitro reconstituted and in in vivo chromatin inspired an intrinsic nucleosome exclusion mechanism in vivo that is based only on DNA and histone properties. However, we compile here published and new evidence that this correlation does not reflect mechanistic causation. (1) Nucleosome depletion over poly(dA:dT) in vivo is not universal, e.g., very weak in

Indexed as

AT Rich SequenceChromatin Assembly and DisassemblyGene Expression Regulation, FungalNucleosomesSaccharomyces cerevisiaeSchizosaccharomycesNucleosomeschromatinnucleosomepoly(dA:dT)remodelingRSCS. cerevisiaeyeast

Identifiers

PMID34360997
PMCPMC8347975
OpenAlexW3191054519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.