Evidence map›Paper›PMID 34360974›Full record

ArticleInternational journal of molecular sciences2021

Effect of Erythropoietin on the Expression of Murine Transferrin Receptor 2.

Betty Berezovsky, Martin Báječný, Jana Frýdlová, Iuliia Gurieva, Daniel Wayne Rogalsky, Petr Přikryl, Vít Pospíšil, Emanuel Nečas, Martin Vokurka, Jan Krijt

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. New Advances in Iron Metabolism, Ferritin and Hepcidin Research.International journal of molecular sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Betty BerezovskyInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Martin BáječnýInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Jana FrýdlováInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Iuliia GurievaInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Daniel Wayne RogalskyInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Petr PřikrylInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.ORCID 0000-0001-6167-2853
Vít PospíšilInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Emanuel NečasInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.ORCID 0000-0002-6101-4639
Martin VokurkaInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Jan KrijtInstitute of Pathophysiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague, Czech Republic.
Charles University · CZ

Funding

Univerzita Karlova v Praze PROGRES Q26Univerzita Karlova v Praze SVV 260519
6 · The paper itself

Abstract

Erythropoietin (EPO) downregulates hepcidin expression to increase the availability of iron; the downregulation of hepcidin is mediated by erythroferrone (ERFE) secreted by erythroblasts. Erythroblasts also express transferrin receptor 2 (TFR2); however, the possible role of TFR2 in hepcidin downregulation is unclear. The purpose of the study was to correlate liver expression of hepcidin with the expression of ERFE and TFR2 in murine bone marrow and spleen at 4, 16, 24, 48, 72 and 96 h following administration of a single dose of EPO. Splenic

Indexed as

AnimalsCells, CulturedCytokinesErythroblastsErythropoietinExosomesHepcidinsLiverMaleMiceMice, Inbred C57BLMuscle ProteinsReceptors, TransferrinSpleenCytokinesErfe protein, mouseErythropoietinHepcidinsMuscle ProteinsReceptors, TransferrinTFR2 protein, mouseerythroferroneexosomeshepcidintransferrin receptor

Identifiers

PMID34360974
PMCPMC8348427
OpenAlexW3190340865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.