Evidence map›Paper›PMID 34360942›Full record

ArticleInternational journal of molecular sciences2021

Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice.

Rossana Di Martino, Maria Josè Sisalli, Rossana Sirabella, Salvatore Della Notte, Domenica Borzacchiello, Antonio Feliciello, Lucio Annunziato, Antonella Scorziello

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Involvement of KAntioxidants (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Article
  8. Neurobiology of Parkinson's Disease.International journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rossana Di MartinoDepartment of Neuroscience, Division of Pharmacology, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
Maria Josè SisalliDepartment of Neuroscience, Division of Pharmacology, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
Rossana SirabellaDepartment of Neuroscience, Division of Pharmacology, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
Salvatore Della NotteDepartment of Neuroscience, Division of Pharmacology, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-9650-7655
Domenica BorzacchielloDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
Antonio FelicielloDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
Lucio AnnunziatoIRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy.
Antonella ScorzielloDepartment of Neuroscience, Division of Pharmacology, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
University of Naples Federico II · ITSDN Istituto di Ricerca Diagnostica e Nucleare · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 2017CY3J3WProgramma Operativo Nazionale Ricerca e Competitività PERMEDNET ARS01_01226
6 · The paper itself

Abstract

The exact mechanism underlying selective dopaminergic neurodegeneration is not completely understood. The complex interplay among toxic alpha-synuclein aggregates, oxidative stress, altered intracellular Ca

Indexed as

alpha-SynucleinAnimalsAstrocytesCalciumCells, CulturedDopaminergic NeuronsMesencephalonMiceMice, Inbred C57BLMitochondriaMutation, MissenseParkinson DiseaseSodium-Calcium Exchangeralpha-SynucleinCalciumSLC38A3 protein, humanSodium-Calcium Exchangermitochondrial dysfunctionneuroinflammationParkinson’s diseaseα-synuclein

Identifiers

PMID34360942
PMCPMC8347885
OpenAlexW3184570608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.