Evidence map›Paper›PMID 34360925›Full record

ArticleInternational journal of molecular sciences2021

Gene Expression Profile of Human Mesenchymal Stromal Cells Exposed to Hypoxic and Pseudohypoxic Preconditioning-An Analysis by RNA Sequencing.

Katarzyna Zielniok, Anna Burdzinska, Victor Murcia Pienkowski, Agnieszka Koppolu, Malgorzata Rydzanicz, Radoslaw Zagozdzon, Leszek Paczek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Katarzyna ZielniokDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland.ORCID 0000-0002-9984-6721
Anna BurdzinskaDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland.
Victor Murcia PienkowskiDepartment of Medical Genetics, Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, Poland.
Agnieszka KoppoluDepartment of Medical Genetics, Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, Poland.
Malgorzata RydzaniczDepartment of Medical Genetics, Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, Poland.
Radoslaw ZagozdzonDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland.ORCID 0000-0002-7957-2372
Leszek PaczekDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland.ORCID 0000-0003-0160-3009
Medical University of Warsaw · PL

Funding

Narodowe Centrum Nauki 2017/25/B/NZ6/01380
6 · The paper itself

Abstract

Mesenchymal stromal cell (MSC) therapy is making its way into clinical practice, accompanied by research into strategies improving their therapeutic potential. Preconditioning MSCs with hypoxia-inducible factors-α (HIFα) stabilizers is an alternative to hypoxic priming, but there remains insufficient data evaluating its transcriptomic effect. Herein, we determined the gene expression profile of 6 human bone marrow-derived MSCs preconditioned for 6 h in 2% O

Indexed as

Cell HypoxiaGene ExpressionMesenchymal Stem CellsAdultCells, CulturedFemaleGlycineHumansMaleMiddle AgedPicolinic AcidsTranscriptomeGlycinePicolinic AcidsvadadustatHIF-1αhypoxic primingmesenchymal stem cellsMSCsPHDs inhibitorRNA-Seqtranscriptional regulationVadadustat

Identifiers

PMID34360925
PMCPMC8348678
OpenAlexW3185223457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.