Evidence map›Paper›PMID 34360851›Full record

ArticleInternational journal of molecular sciences2021

LncRNA

Tan Phát Pham, Anke S van Bergen, Veerle Kremer, Simone F Glaser, Stefanie Dimmeler, Reinier A Boon

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Roles of LncRNAs in the Pathogenesis of Pulmonary Hypertension.Reviews in cardiovascular medicine · 2024
    Review
  6. Review
  7. Advances in Endothelial Cell Biology: From Knowledge to Control.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Tan Phát PhamDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0003-4024-9276
Anke S van BergenDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-1843-5657
Veerle KremerDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Simone F GlaserInstitute of Cardiovascular Regeneration, Goethe University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-0808-2659
Stefanie DimmelerInstitute of Cardiovascular Regeneration, Goethe University, 60590 Frankfurt am Main, Germany.
Reinier A BoonDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLGoethe University Frankfurt · DE

Funding

Deutsche Forschungsgemeinschaft 75732319European Research Council 638178Nederlandse Organisatie voor Wetenschappelijk Onderzoek 91716419
6 · The paper itself

Abstract

Endothelial cells can acquire a mesenchymal phenotype through a process called Endothelial-to-Mesenchymal transition (EndMT). This event is found in embryonic development, but also in pathological conditions. Blood vessels lose their ability to maintain vascular homeostasis and ultimately develop atherosclerosis, pulmonary hypertension, or fibrosis. An increase in inflammatory signals causes an upregulation of EndMT transcription factors, mesenchymal markers, and a decrease in endothelial markers. In our study, we show that the induction of EndMT results in an increase in long non-coding RNA

Indexed as

Epithelial-Mesenchymal TransitionHumansHuman Umbilical Vein Endothelial CellsJumonji Domain-Containing Histone DemethylasesRNA, Long NoncodingSulfotransferasesJumonji Domain-Containing Histone DemethylasesKDM4B protein, humanRNA, Long NoncodingSULF1 protein, humanSulfotransferasesEndMTendothelial cellsNon-coding RNA

Identifiers

PMID34360851
PMCPMC8347915
OpenAlexW3184298355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.