Evidence map›Paper›PMID 34360836›Full record

ArticleInternational journal of molecular sciences2021

LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells.

Talita de S Laurentino, Roseli da S Soares, Antonio M Lerario, Suely K N Marie, Sueli M Oba-Shinjo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. CouldBiomedicines · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Shaping Oncogenic Microenvironments: Contribution of Fibronectin.Frontiers in cell and developmental biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Talita de S LaurentinoCellular and Molecular Biology Laboratory (LIM 15), Neurology Department, Faculdade de Medicina (FMUSP), Universidade de Sao Paulo, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-6279-0437
Roseli da S SoaresCellular and Molecular Biology Laboratory (LIM 15), Neurology Department, Faculdade de Medicina (FMUSP), Universidade de Sao Paulo, Sao Paulo 01246-000, SP, Brazil.
Antonio M LerarioDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA.
Suely K N MarieCellular and Molecular Biology Laboratory (LIM 15), Neurology Department, Faculdade de Medicina (FMUSP), Universidade de Sao Paulo, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0003-4419-7928
Sueli M Oba-ShinjoCellular and Molecular Biology Laboratory (LIM 15), Neurology Department, Faculdade de Medicina (FMUSP), Universidade de Sao Paulo, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-1650-5973

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 140482/2020-2Fundação de Amparo à Pesquisa do Estado de São Paulo #2015/03614-5Fundação de Amparo à Pesquisa do Estado de São Paulo #2016/05777-1Fundação de Amparo à Pesquisa do Estado de São Paulo #2020/02988-9
6 · The paper itself

Abstract

Lysyl oxidase-like 3 (LOXL3), belonging to the lysyl oxidase family, is responsible for the crosslinking in collagen or elastin. The cellular localization of LOXL3 is in the extracellular space by reason of its canonical function. In tumors, the presence of LOXL3 has been associated with genomic stability, cell proliferation, and metastasis. In silico analysis has shown that glioblastoma was among tumors with the highest

Indexed as

Cell AdhesionGene Expression Regulation, NeoplasticAmino Acid OxidoreductasesCell Line, TumorCell ProliferationComputer SimulationCytoskeletonEndocytosisExtracellular MatrixGene Expression ProfilingGlioblastomaHumansLysosomesNeoplasm InvasivenessAmino Acid OxidoreductasesLOXL3 protein, humancell deathcytoskeletonendocytosisextracellular matrixglioblastomaLOXL3lysyl oxidase

Identifiers

PMID34360836
PMCPMC8347215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.