Evidence map›Paper›PMID 34360835›Full record

ArticleInternational journal of molecular sciences2021

Rana Al-Sadi, Viszwapriya Dharmaprakash, Prashant Nighot, Shuhong Guo, Meghali Nighot, Toan Do, Thomas Y Ma

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Intestinal-Bone Axis Mediated byMicroorganisms · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Associations of human milk lactoferrin with measures of physical growth in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bioscience of microbiota, food and health · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rana Al-SadiDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.
Viszwapriya DharmaprakashDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.
Prashant NighotDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.
Shuhong GuoDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.
Meghali NighotDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.
Toan DoDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.
Thomas Y MaDepartment of Medicine, Penn State College of Medicine, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA.ORCID 0000-0001-9011-8050
Penn State Milton S. Hershey Medical Center · US

Funding

Intestinal Barrier, Probiotic Bacteria, and the Gut-Liver AxisR01DK121073 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MA, THOMAS Y · 2019 to 2023
$2.4M
Bifidobacterium bifidum modulation of intestinal barrier and intestinal inflammation.R01DK106072 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MA, THOMAS Y · 2016 to 2019
$1.8M
Regulation of Intestinal Tight Junction Barrier and Inflammation by AutophagyR01DK114024 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI NIGHOT, PRASHANT · 2017 to 2021
$1.8M
Role of the chloride channel ClC-2 in intestinal tight junction barrier recoveryK01DK100562 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI NIGHOT, PRASHANT · 2014 to 2018
$684k
NIDDK NIH HHS Grants R01-DK-114024NIDDK NIH HHS K01-DK-100562NIDDK NIH HHS R01 DK106072NIDDK NIH HHS R0-1-DK-106072-01NIDDK NIH HHS R01 DK114024NIDDK NIH HHS R01 DK121073NIDDK NIH HHS R01-DK-121073-01
6 · The paper itself

Abstract

Defective intestinal tight junction (TJ) barrier is a hallmark in the pathogenesis of inflammatory bowel disease (IBD). To date, there are no effective therapies that specifically target the intestinal TJ barrier. Among the various probiotic bacteria,

Indexed as

Signal TransductionTight JunctionsAnimalsBifidobacterium bifidumCaco-2 CellsColitisHumansIntestinal MucosaMiceNF-kappa BPermeabilityProbioticsToll-Like Receptor 2NF-kappa BToll-Like Receptor 2Bifidobacteriumintestinal barriertoll-like receptor-2

Identifiers

PMID34360835
PMCPMC8347470
OpenAlexW3185881008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.