Evidence map›Paper›PMID 34360825›Full record

ReviewInternational journal of molecular sciences2021

Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System.

Mariana Vassal, Sandra Rebelo, Maria de Lourdes Pereira

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  12. Antimicrobial Activity ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariana VassalDepartment of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Sandra RebeloNeuroscience and Signalling Laboratory, Institute of Biomedicine (iBiMED), University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-5862-5797
Maria de Lourdes PereiraDepartment of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-6703-7869

Funding

Fundação para a Ciência e a Tecnologia Institute of Biomedicine (iBiMED) UID/BIM/04501/2020.Fundação para a Ciência e a Tecnologia Project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 and UIDP/50011/2020
6 · The paper itself

Abstract

Metal oxide nanoparticles (MONPs) are inorganic materials that have become a valuable tool for many industrial sectors, especially in healthcare, due to their versatility, unique intrinsic properties, and relatively inexpensive production cost. As a consequence of their wide applications, human exposure to MONPs has increased dramatically. More recently, their use has become somehow controversial. On one hand, MONPs can interact with cellular macromolecules, which makes them useful platforms for diagnostic and therapeutic interventions. On the other hand, research suggests that these MONPs can cross the blood-testis barrier and accumulate in the testis. Although it has been demonstrated that some MONPs have protective effects on male germ cells, contradictory reports suggest that these nanoparticles compromise male fertility by interfering with spermatogenesis. In fact, in vitro and in vivo studies indicate that exposure to MONPs could induce the overproduction of reactive oxygen species, resulting in oxidative stress, which is the main suggested molecular mechanism that leads to germ cells' toxicity. The latter results in subsequent damage to proteins, cell membranes, and DNA, which ultimately may lead to the impairment of the male reproductive system. The present manuscript overviews the therapeutic potential of MONPs and their biomedical applications, followed by a critical view of their potential risks in mammalian male fertility, as suggested by recent scientific literature.

Indexed as

AnimalsGenitalia, MaleHumansMaleMetal NanoparticlesOrganic ChemicalsOxidative StressOxidesReactive Oxygen SpeciesSpermatogenesisOrganic ChemicalsOxidesReactive Oxygen Speciesbiomedicinemale infertilitymetal-oxide nanoparticlesnanotoxicityoxidative stressreproductive systemspermatogenesis

Identifiers

PMID34360825
PMCPMC8348343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.