Evidence map›Paper›PMID 34360819›Full record

ReviewInternational journal of molecular sciences2021

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy.

Kacper Pobłocki, Joanna Drzeżdżon, Tomasz Kostrzewa, Dagmara Jacewicz

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Applications of Metal-Organic Frameworks as Drug Delivery Systems.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kacper PobłockiDepartment of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.ORCID 0000-0001-6428-1495
Joanna DrzeżdżonDepartment of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.ORCID 0000-0002-9964-3027
Tomasz KostrzewaDepartment of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland.ORCID 0000-0002-6081-2049
Dagmara JacewiczDepartment of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.

Funding

Medical University of Gdańsk Grant ("Excellence Initiative - Research University") 664/259/63/73-3319
6 · The paper itself

Abstract

Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.

Indexed as

PhotochemotherapyCell Line, TumorHumansMetal-Organic FrameworksNeoplasmsPhotosensitizing AgentsReactive Oxygen SpeciesMetal-Organic FrameworksPhotosensitizing AgentsReactive Oxygen Speciescancer therapycopper(0,I)-based complexesiridium(III)-based complexesosmium(0,II)-based complexesphotodynamic therapyphotosensitizersplatinum(0)-based complexesreactive oxygen speciesreactive singlet oxygenruthenium(II)-based complexes

Identifiers

PMID34360819
PMCPMC8348047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.