Evidence map›Paper›PMID 34360806›Full record

ArticleInternational journal of molecular sciences2021

Antiradical Properties of N-Oxide Surfactants-Two in One.

Agnieszka Lewińska, Julita Kulbacka, Marta Domżał-Kędzia, Maciej Witwicki

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Medicinal Chemistry of Drugs withJournal of medicinal chemistry · 2024
    Review
  3. Article
  4. Formation and structural features of micelles formed by surfactin homologues.Frontiers in bioengineering and biotechnology · 2023
    Article
  5. Structurally Related Liposomes ContainingMolecular pharmaceutics · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Agnieszka LewińskaFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wroclaw, Poland.ORCID 0000-0001-9821-8793
Julita KulbackaDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-367 Wroclaw, Poland.ORCID 0000-0001-8272-5440
Marta Domżał-KędziaDepartment of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.ORCID 0000-0002-4001-9983
Maciej WitwickiFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wroclaw, Poland.ORCID 0000-0002-9347-2538

Funding

Narodowe Centrum Badań i Rozwoju POIR.01.01.01-00-0729/19Wroclawskie Centrum Sieciowo-Superkomputerowe, Politechnika Wroclawska 47
6 · The paper itself

Abstract

Surfactants are molecules that lower surface or interfacial tension, and thus they are broadly used as detergents, wetting agents, emulsifiers, foaming agents, or dispersants. However, for modern applications, substances that can perform more than one function are desired. In this study we evaluated antioxidant properties of two homological series of N-oxide surfactants: monocephalic 3-(alkanoylamino)propyldimethylamine-N-oxides and dicephalic N,N-bis[3,3'-(dimethylamino)propyl]alkylamide di-N-oxides. Their antiradical properties were tested against stable radicals using electron paramagnetic resonance (EPR) and UV-vis spectroscopy. The experimental investigation was supported by theoretical density functional theory (DFT) and ab initio modeling of the X-H bonds dissociation enthalpies, ionization potentials, and Gibbs free energies for radical scavenging reactions. The evaluation was supplemented with a study of biological activity. We found that the mono- and di-N-oxides are capable of scavenging reactive radicals; however, the dicephalic surfactants are more efficient than their linear analogues.

Indexed as

Electron Spin Resonance SpectroscopyFree Radical ScavengersSurface-Active AgentsFree Radical ScavengersSurface-Active Agentsantioxidantantiradical propertiesDFTDLPNO-CCSD(T)EPR spectroscopyradical scavengingsurfactantsUV-vis spectroscopy

Identifiers

PMID34360806
PMCPMC8346996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.