Evidence map›Paper›PMID 34360797›Full record

ArticleInternational journal of molecular sciences2021

Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections.

Iwona E Głowacka, Magdalena Grabkowska-Drużyc, Graciela Andrei, Dominique Schols, Robert Snoeck, Karolina Witek, Sabina Podlewska, Jadwiga Handzlik, Dorota G Piotrowska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Phosphorylated Nitrones-Synthesis and Applications.Molecules (Basel, Switzerland) · 2025
    Review
  2. Synthesis of biologically active cefpodoxime and vanillin-based schiff base metal complexes with the detailed biological evaluations.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Iwona E GłowackaBioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0001-7567-5860
Magdalena Grabkowska-DrużycBioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0002-4230-0218
Graciela AndreiKU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Herestraat 49, Box 1030, B-3000 Leuven, Belgium.ORCID 0000-0003-2609-4896
Dominique ScholsKU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Herestraat 49, Box 1030, B-3000 Leuven, Belgium.ORCID 0000-0003-3256-5850
Robert SnoeckKU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Herestraat 49, Box 1030, B-3000 Leuven, Belgium.
Karolina WitekDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.
Sabina PodlewskaDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-2891-5603
Jadwiga HandzlikDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-3674-3581
Dorota G PiotrowskaBioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0003-3792-8796
Jagiellonian University · PLMedical University of Lodz · PLRega Institute for Medical Research · BE

Funding

Jagiellonian University Medical College N42/DBS/000196Narodowym Centrum Nauki UMO-2015/17/B/ST5/00076Rega Foundation Rega Foundation
6 · The paper itself

Abstract

A novel series of N-substituted

Indexed as

Adjuvants, PharmaceuticAnti-Bacterial AgentsAntiviral AgentsAzetidinesBacterial Proteinsbeta-LactamasesCell Line, TumorCell ProliferationCoronavirus 229E, HumanCytostatic AgentsHumansInfectionsInfluenza A Virus, H1N1 SubtypeMolecular Dynamics SimulationOxacillinPenicillin-Binding ProteinsAdjuvants, PharmaceuticAnti-Bacterial AgentsAntiviral AgentsAzetidinesBacterial Proteinsbeta-LactamasesCytostatic AgentsmecA protein, Staphylococcus aureusOxacillinPenicillin-Binding Proteinsantibiotic adjuvantantiviralcytostaticmolecular dockingmolecular dynamicsMRSAPBP2aphosphonatesβ-lactams

Identifiers

PMID34360797
PMCPMC8348901
OpenAlexW3183482435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.